Presentation on theme: "Bone and soft tissue tumors Imad Fadl-Elmula Al Neelain University."— Presentation transcript:
Bone and soft tissue tumors Imad Fadl-Elmula Al Neelain University
THE CLINICAL SCENARIO From Rydholm and Pettersson May occur at all ages Most common in the extremities Benign>>malignant Poor prognosis for malignant tumours (sarcomas) Treatment choices: Radical or conservative surgery? Chemotherapy? Radiotherapy?
Disease Mechanisms? Environmental: 1. Radiation. 2. Viruses. Inherited factors: Li-Fraumeni syndrome. Von Recklinghausen disease. DNA 3D structure Acquired genetic changes:
Bone and soft tissue lesions – somatic mutations Simple changes Rings and markers Complex changes Benign Borderline malignant Malignant