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Institute of Virology Justus-Liebig-University Giessen Federal agency for sera and vaccines Verena Jakel FACTORS INFLUENCING THE ANTIBODY RESPONSE TO RABIES.

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Presentation on theme: "Institute of Virology Justus-Liebig-University Giessen Federal agency for sera and vaccines Verena Jakel FACTORS INFLUENCING THE ANTIBODY RESPONSE TO RABIES."— Presentation transcript:

1 Institute of Virology Justus-Liebig-University Giessen Federal agency for sera and vaccines Verena Jakel FACTORS INFLUENCING THE ANTIBODY RESPONSE TO RABIES VACCINATION V.Jakel 1 K.Cussler 2, M.König 1, H.-J.Thiel 1 1 Institute of Virology, Justus-Liebig-Universität Giessen, Germany 2 Paul-Ehrlich-Institut, Langen, Germany

2 Verena Jakel Introduction Dogs and cats vaccinated against rabies according to recommendations of manufacturer may fail to reach the titre of 0,5 IU/ml required for travel purposes Cliquet, 2003: 7,4% dogs 1,9% cats Mansfield, 2004: 5,2% dogs 2,7% cats (lab 1) 4,1% dogs 2,9% cats (lab 2) Survey Paul-Ehrlich-Institut, 2004: 10-18% dogs 0-5% cats (lab 1 – 3)

3 Verena Jakel Material and Methods Sera tested by FAVN assay Questionnaire sent to veterinarians of dogs and cats tested for travel purposes Separate data query for animals with test result < 0,5 IU/ml (test failed) and 0,5 IU/ml (test passed) < 0,5 IU/ml 0,5 IU/ml Dogs Cats197493

4 Verena Jakel Primovaccinated dogs have a 6-fold higher risk for test failure than multivaccinated dogs. Influences on test result I: previous vaccinations dogscats OR 6.52, p<0.0001, 95%-CI: 4.9 – 8.7 OR 8.49, p=0.0019, 95%- CI: 2.2 – 32.8

5 Verena Jakel Primovaccinated dogs tested more than 120 days after vaccination have a 3,27 fold higher risk for test failure than dogs tested during the first four months after vaccination Influences on test result II (dogs): time vaccination - blood sampling

6 Verena Jakel Travel destinations (all animals)

7 Verena Jakel Influences on test result III (dogs): Vaccine 4 different rabies virus strains for inactivated vaccines in use in Germany

8 Verena Jakel Influences on test result III (dogs): Vaccine Vaccine strainOR95%-CIP * -value < < < < *αi Bonferroni-Holm adjusted for multiple tests Dogs vaccinated with vaccine strains 2 or 3 have a lower risk for test failure than dogs vaccinated with vaccine strain 1 or 4

9 Verena Jakel Influences on test result IV (dogs): Vaccine Dogs vaccinated with monovalent vaccines have a lower risk for test failure (OR 0.662, 95%-CI: , p=0.0007)

10 Verena Jakel Summary Significant influence on test outcome: Number of rabies vaccinations animal has received in lifetime Time between vaccination and blood sampling Strain of rabies vaccine Vaccine formulation No significant influence on test outcome: Sex Medical treatment in parallel to rabies vaccination Travel regulations frequently not complied

11 Verena Jakel Overall compliance of regulations

12 Verena Jakel Conclusions Booster vaccination necessary in dogs and young cats to enhance probability of test result of 0,5 IU/ml Significant differences between vaccines to induce rabies virus neutralizing antibodies Harmonization of regulations for better compliance compulsory

13 Verena Jakel Outlook Additional statistical analysis of data on influence of vaccination history and vaccines Influence of test virus strain (CVS) and vaccine strains on FAVN results

14 Verena Jakel C. Förster M. Lenhard S. Deike B. Bank-Wolf Dr. D. Chauvet Institute of Virology Justus-Liebig-University Giessen Acknowledgements PD Dr. A. Hoffmann Dr. A. Mergel The study was financially supported by the Federal Ministry of Food, Agriculture and Consumer Protection (BMVEL), Germany Federal agency for sera and vaccines


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