Presentation is loading. Please wait.

Presentation is loading. Please wait.

IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1) (1) Pokrov Plant of Biologics, Volginskiy,

Similar presentations


Presentation on theme: "IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1) (1) Pokrov Plant of Biologics, Volginskiy,"— Presentation transcript:

1 IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1) (1) Pokrov Plant of Biologics, Volginskiy, Russia. (2) All-Russian Research Institute of Veterinary Virology and Microbiology, Pokrov, Russia. and Microbiology, Pokrov, Russia.

2 Oral vaccination Two oral vaccines have been used for wild life rabies vaccination in Russia Two oral vaccines have been used for wild life rabies vaccination in Russia Not enough vaccine quantity have been used for ORV campaigns Not enough vaccine quantity have been used for ORV campaigns There was concern about safety and efficacy of vaccine rabies strains There was concern about safety and efficacy of vaccine rabies strains Russia still needs a safe and efficient vaccine strain Russia still needs a safe and efficient vaccine strain

3 ERA G 333 Created by reversed genetics Created by reversed genetics Have been received from collaborators at CDC Have been received from collaborators at CDC As part of BTEP program As part of BTEP program Avirulent for 11 species of target and non target animals Avirulent for 11 species of target and non target animals

4 The immunogenicity experiment design. Part I: foxes Species# VNA titers, IU/ml Day of death Comments Before challenge Day 30 after challenge Day 60 after challenge fox fox2< fox fox4< fox fox fox fox8< fox fox fox11< th fox12< th unvaccinated control fox13< th unvaccinated control fox14< st unvaccinated control

5 The immunogenicity experiment design. Part II: raccoon dogs Species# VNA titers, IU/ml Day of death Comments Before challenge Day 30 after challenge Day 60 after challenge Raccoon dog < th unvaccinated control Raccoon dog 5< th Raccoon dog 6< th Raccoon dog 7< < st Raccoon dog 9< th Raccoon dog 10< nd unvaccinated control Raccoon dog 11< th unvaccinated control

6 63% of foxes and 33% of raccoon dogs showed seroconversion by day 60 after vaccination. After challenge with virulent rabies virus strain 90% of foxes and 50% of raccoon dogs have survived. RESULTS

7 CONCLUSIONS The appropriate immunogenicity of ERA G 333 for foxes and raccoon dogs has been shown in this experiment. The appropriate immunogenicity of ERA G 333 for foxes and raccoon dogs has been shown in this experiment. This strain is the strong candidate for new oral rabies vaccine. This strain is the strong candidate for new oral rabies vaccine. The decision about future use of ERA G 333 strain can be made after the determination of immunity duration and minimal efficient doze of the vaccine virus. The decision about future use of ERA G 333 strain can be made after the determination of immunity duration and minimal efficient doze of the vaccine virus.

8 ACKNOWLEDGEMENTS Pokrov Plant of Biologics Pokrov Plant of Biologics Staff of the Rabies Program of CDC Staff of the Rabies Program of CDC BTEP BTEP


Download ppt "IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1) (1) Pokrov Plant of Biologics, Volginskiy,"

Similar presentations


Ads by Google