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Calcium binding proteins Maria Tereshina Vsevolod Belousov
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Calcium binding protein CaBP2 Results of CD search by BLAST reveal two Efh domains
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Calcium binding protein CaBP2 Results of CD search by BLAST reveal two Efh domains, each consisting of ef-hand motifs
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Stricture of typical ef-hand containing protein, calmodulin
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+4Ca 2+
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N-terminal domain of calmodulin with bound Ca 2+ Yellow- key positions in ef-hand, coordinating Ca 2+ (usually Asp & Glu)
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N-terminal domain of calmodulin with bound Ca 2+ Yellow- key positions in ef-hand, coordinating Ca 2+ (usually Asp & Glu)
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Calsequestrin - ER protein with negatively charged surface that binds Ca 2+ with low affinity
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Crystal structure of calsequestrin. Red spacefill- Asp & Glu residues
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C2 domains- Ca 2+ -dependent lipid binding folds
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Structure of C2 domain from PKC Yellow- Asp residues coordinating Ca 2+
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Novel Ca2+ binding domain in bacterial collagenases
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Structure of Ca 2+ -binding domain of collagenase Conformation changes upon Ca 2+ load
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Structure of Ca 2+ -binding domain of collagenase Conformation changes upon Ca 2+ load
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CONCLUSION The diversity of calcium binding proteins is great!
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