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Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.

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Presentation on theme: "Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover."— Presentation transcript:

1 Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover haller.hermann@mh-hannover.de

2 The problem: how translate risk factors into vascular disase ? Risk factors Vascular damage subclinical Clinical disease years and decades glucose lipids smoking hypertension

3 The problem: how to recognize these patients ? Risk factors Vascular damage subclinical Clinical disease years and decades glucose lipids smoking hypertension

4 phenotyping - what are we looking for ? hypertension Oxidative stress Micro- inflammation

5 EM Gefäß

6 Permeability NONOS NO NO Non-adhesive Healthy endothelium

7 NONOS NO NO Non-adhesive Healthy endothelium Hypertension Glucose Cholesterol risk factors factors ROS ROS Oxidases NOS NOSinhibitors Chemokines Permeability Permeability

8 Permeability NONOS NO NO Non-adhesive Healthy endothelium Permeability Oxidases ROS ROS NOS NOSinhibitors Chemokines Hypertension Glucose Cholesterol risk factors factors

9 EM Leukozytenadhäsion

10 Permeability NONOS NO NO Non-adhesive Healthy endothelium Permeability Oxidases ROS ROS NOS NOSinhibitors Chemokines MCP-1, CCR-7 etc selectins Hypertension Glucose Cholesterol risk factors factors


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