1. MEDICONTUR – Natural Yellow Filter When a technology follows the nature..

2. „The addition of a covalently bound yellow dye results in a IOL UV/visible light transmittance curve that mimics the protection provided by the natural, precataractous adult human crystalline lens. There is an indirect evidence showing that this addition may result in a reduction Of the risk for macular degeneration and progression..“ Werner, Biocompatibility of intraocular lens materials; 2008 Wolters Kluwer Health „Some manufactures adopted to an approach of a violet light-filtering chromophore based o studies that UV radiation and violet radiation 400-440nm have substantial potential acute UV/blue phototoxicity while Blue light (440-500nm) has significant potential acute UV/blue phototoxicity, but it is vital for scotopic vision“ Werner, Biocompatibility of intraocular lens materials; 2008 Wolters Kluwer Health

3. Blue light is more important for scotopic (night time) than photopic (day time) vision. Scotopic sensitivity declines twice as fast with aging as does photopic sensitivity; therefore night vision is a major problem for older adults. Clear IOLs – only UV blockers – have potential to improve a night vision Scotopic and photopic luminous efficiencies peak at 507 nm (bl-green) and 555 (gr-yellow) Alcon yellow – blocks 50% at 450nm and 25% at 480nm Blue light – potential to have retinal phototoxicity; there is not definitive conclusion about the relationship between visible light and AMD… L Werner at al.: New photochromic foldable IOLs: Preliminary study of feasibility and biocompatibility; J Cataract Surg 2006;32:1214-1221

4. Blue light is not associated with AMD: 9 of 11 major epidemiological studies show no correlation between AMD and lifelong light exposure1 Factors that have been correlated with AMD are: 1) Age 2) Genetics 3) Smoking 4) Nutrition Blue light has been proven to be essential for: Optimal scotopic vision1 Healthy circadian rhythms2-4 Mainster. BJO. 2006. 2. Lehrl. JNT. 2006. 3. Cajochen. EJN. 2006. 4. Mirjam-Munch. AJP. 2006.

5. Blue light provides 35% of scotopic sensitivity Melatonin suppression is controlled by blue light sensitive retinal ganglion cells Blue light provides 55% of melatonin suppression* Mainster. BJO. 2006. 2. Werner. BJO. 2005. 3. Schwiegerling J. JCRS. 2006.

6. To Block or Not to Block Blue Light?

7. MEDICONTUR „natural yellow filter approach“

8. "Natural" yellow filter Filtering as much as necessary – preserving as much as possible. For a balanced protection of the macula against UV-A and blue light by an absorption curve close to that of the human crystalline lens, preserving the natural colour perception and contrast sensitivity.

10. 01.09.10 „Natural Yellow the Medicontur IOL“ Filtering as much as necessary – preserving as much as possible.