1. The VIZIER project Coord. : B. Canard AFMB, CNRS/University of Marseille France Preparing Europe for the Next Viral Outbreak

2. Major causes of human death: Major causes of human death: Most are RNA viruses.

3. A today alarming situation

4. rotavirus virus Ebola virus Hantaan HTLV-1 HIV Hépatite E Hépatite C virus Guanarito / Machupo virus Sin Nombre virus Hendra grippe virus Nipah RVFV virus Chikungunya virus West Nile SARS-CoV virus de la dengue encéphalite Japonaise monkeypox herpesvirus-8 Génome ARN Struct genomic Southern countries BSL Zoonose Arbovirose Vaccines Antivirals Kits S / MB-A Very few weapons to fight them. Killing agents:

5. Goal : Identification of new targets from RNA viruses through a structural characterization of the replicative system Structural Genomics project supported by the European Union Started in November 2004 up to (at least) October 2008 Means : 25 partners (public and corporate research centers) >100 full time researchers involved 13 M funding by EEC What is VIZIER?: VIral enZymes InvolvEd in Replication A common effort to tackle this issue.

6. VIZIER members and Partnership Section 1 Bioinformatics Viralis VaZyMolO Alexander Gorbalenya Section 2 Virology Xavier De Lamballerie Section 3 Production Bruno Coutard (vice coordinator) Section 4 Crystallization Alwyn Jones Section 5 Validation Johan Neyts