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Sustainable Medicine New Directions for Research David Servan-Schreiber, MD, Ph.D Clinical Professor of Psychiatry, University of Pittsburgh Lecturer,

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Presentation on theme: "Sustainable Medicine New Directions for Research David Servan-Schreiber, MD, Ph.D Clinical Professor of Psychiatry, University of Pittsburgh Lecturer,"— Presentation transcript:

1 Sustainable Medicine New Directions for Research David Servan-Schreiber, MD, Ph.D Clinical Professor of Psychiatry, University of Pittsburgh Lecturer, Faculté de Médecine Lyon

2 Current Model

3 The Tibetan Principle Myocardial infarction, Pneumonia, Appendicitis… CAD, Cancer, Diabetes, Depression, Arthritis...

4 Coronary Artery Disease Ornish, 1995 JAMA –Treatment as usual –Vegetarian diet + exercise + meditation + group support Program Control Baseline5 years later Myocardial Perfusion 13 N PET Scan

5 A Story Pittsburgh, late1992

6 Epidemic 1 - Evolution SEER, 2003 NCI

7 Epidemic 2 - Distribution

8 Key difference = Lifestyle For 100,000 Sasco, 1989 Rev Med Int

9 Prevention AND Treatment Lifestyle factors can cause or protect from cancer Can they affect treatment too?

10 Andersen et al., 2008 Cancer Behavioral Changes and Breast Cancer Intervention Control 68% reduction in mortality

11 Nutrition

12 Mediterranean Diet Eposito et al, 2004 JAMA

13 Omega-3 / Omega-6 Feller et al., Jal. Am. Chem. Soc.., 2002

14

15 Duckett et al., 1993 J Animal Sci

16 Ailhaud et al., Prog. Lip. Res., 2006 – Simopoulos & Salem. NEJM, 1989 Omg-6 /Omg-3 x6 x10 x15 x20 Transformation of food chain

17 Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories M - 10, WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut Evolution of Diet

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20 Omega-6 fatty acids and mammary tumors Carroll et al, 1975 Cancer Res. Days post graft Nb of tumors

21 Advanced Breast Cancer Gago-Dominguez et al., 2003 Brit J Ca – Singapore Prospective women

22 Membrane Protection Florent et al. Jal. Neurochem., 2006 Neurones without anything Neurones exposed to beta-amyloid Neurones with omg3 Neurones with omg3 exposed to beta-amyloid

23 Prevention: Framingham Study Schaefer et al, 2006 Arch Neurol. RR=0.53

24 Treatment: Omega-3 AD Study Freund-Levi et al, 2006 Arch Neurol. Omega-3 Placebo

25 Statins or Omega-3s? -22% -32% Cardiac Mortality Studer et al, Arch Int. Med. 2005

26 Statins or Omega-3s? -13% -23% All Cause Mortality Studer et al, Arch Int. Med. 2005

27 Flaxseed Project 5% flax seed in animal feed Meat, butter, eggs, cheese, milk balanced in omega-3s Impact on human biological parameters (INRA, CHU Rennes, CHU Lorient)

28 Childhood Cancers - Europe Steliarova-Foucher et al., 2005 Lancet

29 Organic vs Conventional Food 42 children 2 to 5 yo - Seattle, Wash « organic » children below EPA safety limit « conventional » children 4 x above Curl et al., 2003 Env. Health. Persp.

30 Summary Many scientifically sound complementary and environmental approaches Which is the best medicine? Which is more scientific? No patent = no profits = no awareness

31 Sent: Thur. 02/28/08 5:40 pm To: XXX Great. Thanks. G is a great guy, say hi, and I will keep looking out for the good science he does. Even so, the chances of commercial success hinge on the patent life of a molecule, and we have our hands full with stuff that has that sort of potential. Best, XXX Clinical Director, XXX

32 New Research Orientations 1. Natural/sustainable treatments 2. Intellectual property protection 3. Environmental interventions

33 The End


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