1. CORPORATE INNOVATION AS AN ENGINE FOR CHANGE: Molecular Diagnostics David Okrongly, Ph.D. SVP Molecular Diagnostics Siemens Healthcare

2. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. Magnetic Resonance In Vivo Diagnostics (Major Medical Imaging Systems) Computed Tomography X-ray Molecular Imaging Immunoassay Clinical Chemistry MolecularHematology Lab Automation Urinalysis Blood Gas In Vitro Diagnostics (Major Medical Laboratory Systems) The Era of the Integrated Diagnostics Company is Here Healthcare IT Ultrasound Preclinical Imaging Integrated medical data translated into actionable knowledge

3. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. Global health care spending is accelerating Global Health Care 4% 15% Global Diagnostics Source: World Medical Markets Fact Book 2007, SG Cowen, Kalorama, TriMark, Management Estimate New science and aging population further burden spending $US Bil Source: SG Cowen <2% 70% Healthcare spent on IVDClinical decision contribution Are we utilizing the Diagnostic Toolbox well?

4. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. Highly Active Antiretroviral Drug Therapy H AAR T NRTINRTI NNRTI EI PI INT NRTI PI NRTI EI NRTI INT NNRTI Most common EI INT NEW COMBO TX EI

5. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. Cancer Represents a Much More Challenging Picture Monoclonal Antibodies Small Molecule Inhibitors

6. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. How to treat Node Negative Breast Cancer …  Molecular markers like Ki67, ErbB2, … Basic Risk Categories of Node- negative Breast Cancer Patients without treatment Current Treatment according to Guidelines Treatment decisions according to molecular classification NT

7. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved. Risk of MI Cardiac Risk Assessment High risk Intermediate risk Low risk 77.5% 15% 7.5% How??? Molecular Diagnostics # of MIs ~33%

8. Copyright © 2008 Siemens Healthcare USA, Inc. All rights reserved.

9. The Era of Molecular Medicine Knowledge-Driven IT In Vitro Diagnosis Integrate medical information and enable knowledge-driven clinical applications Molecular Medicine Leverage novel molecular technologies for risk assessment, early detection and diagnosis of disease Systems IT Applications Assays Molecular Imaging Visualize and localize molecular processes in vivo for diagnosis and therapy SystemsBiomarkers Clinical Applications

11. TRANSFORMING PATHOLOGY: Emerging technology driving practice innovation