Presentation on theme: "Immunity and Vaccines Immune system Virus persistence Immunity / memory / vaccines Neutr. Ab: successful vaccines!"— Presentation transcript:
Immunity and Vaccines Immune system Virus persistence Immunity / memory / vaccines Neutr. Ab: successful vaccines!
Prevent penetration IgA systemic neutr.-opson.IgM/G adoptive transferable IgG IgM 1-2d, regulated by Ag-dose and structure (no negative selection) Control-elim. intracell parasites also in solid organs regulate longterm IgG cause imunopathology (negative selection) T B Ab
IMMUNO- PATHOLOGY: V known V IMMUNOPROTECTION IMMUNOPATHOLOGY V V AUTOIMMUNITIY: V not known unrecognized endogenous VS.
glycoprotein: LCMV-GPglycoprotein:IND-G rLCMV/INDGrVSV/LCMV-GP reverse genetic glycoprotein exchange between LCMV and VSV LCMVVSV-IND glycoprotein: LCMV-GPglycoprotein:IND-G
Only VSVG expressing viruses induce a neutralizing antibody response
Why autoimmune disease in humans mostly via antibodies? Why>> ! Why all vaccines that function protect via neutr. antibodies? First infection kills host: no memory needed Host survives first infection: memory not necessary
persistent virus from mother
Poliomyelitis – age distribution in Massachusetts 1912 – 1952