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LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental knowledge and basic tools for functional genomics in all organisms Meeting of the National.

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Presentation on theme: "LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental knowledge and basic tools for functional genomics in all organisms Meeting of the National."— Presentation transcript:

1 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental knowledge and basic tools for functional genomics in all organisms Meeting of the National Contact Points 23/10/2002 Brussels Indridi Benediktsson

2 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP 7 Thematic Priorities M 1 Life sciences, genomics and biotechnology for health Information society technologies Nanotechnologies and nano-sciences, knowledge- based multifunctional materials & processes Aeronautics and space Food quality and safety Sustainable development, global change and ecosystems Citizens and governance in a knowledge-based society 225

3 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP 1.1 Advanced genomics and its applications for health ( 1,100 M) Fundamental knowledge and basic tools for functional genomics in all organisms Application of knowledge and technologies in the field of genomics and biotechnology for health 1.2 Combating major diseases ( 1,155 M) Application-oriented genomic approaches to medical knowledge and technologies Combating cancer Confronting the major communicable diseases linked to poverty Life sciences, genomics and biotechnology for health

4 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental knowledge and basic tools for functional genomics in all organisms Gene expression and proteomics Structural genomics Comparative genomics and population genetics Bioinformatics Multidisciplinary functional genomics approaches to basic biological processes Life sciences, genomics and biotechnology for health Fundamental genomics

5 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental genomics Gene expression and proteomics Developing high throughput tools and approaches for monitoring gene expression and protein profiles and for determining protein function and protein interactions Structural genomics Developing high throughput approaches for determining high- resolution 3-D structures of macromolecules Comparative genomics and population genetics Developing model organisms and transgenic tools; developing epidemiology tools and standardised genotyping protocols

6 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Bioinformatics Developing bioinformatics tools and resources for data storage, mining and processing; developing computational biology approaches for in silico prediction of gene function and for the simulation of complex regulatory networks Multidisciplinary functional genomics approaches to basic biological processes Elucidation of the mechanisms underlying fundamental cellular processes, to identify the genes involved and to decipher their biological functions in living organisms Fundamental genomics

7 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Expressions of Interest Invitation to submit: 20 March 2002 (Electronic submission) Deadline for EoIs: 7 June 2002 Criteria: 1. Quality of the rationale, objectives, general approach 2. Need and relevance 3. Excellence 4. For NoEIntegration and structuring effect (addressing fragmentation) For IPIntegration (delivering specific results)

8 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP ANALYSIS METHODOLOGY Remote assessment prior to the panel meeting individual scores and citation lists of top 15 EoIs Discussion at the panel meeting definition of priority topics for IP and NoE Peer review by panels of high level experts Expressions of Interest - no pre-selection of particular EoIs or consortia

9 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Fundamental genomics Expressions of Interest: Overall response (total: 523) IP : NoE approximate ratio 2:1 Bioinfor- matics Gene expression and proteomics Structural genomics Basic biological processes Not relevant (reassigned) Comparative genomics and population genetics

10 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP The experts recommended 30 topics in total Each topic represents on the average 3 EoIs About 15 topics could be open in each of the two calls The selected topics will be open only for the call indicated Competition between topics and within topic areas Some topic areas which are open might end up not being supported (depending on quality of the proposals) Fundamental genomics

11 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Recommended topics from the EoIs Development of advanced array technologies for proteins, DNA and RNA Development and application of high throughput proteomics technologies for the generation of a large data set of protein- protein interactions Global in situ gene expression analysis in mouse models and human tissue Gene expression and proteomics

12 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Structural genomics High throughput 3D-structure determination of membrane proteins Supramolecular analysis by 3D-electron microscopy in situ Development of new hardware and software for the implementation of innovative automated technologies at synchrotron sites Comparative structural biology of viral replication Structure determination of large protein complexes Recommended topics from the EoIs

13 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Comparative genomics and population genetics Non-mammalian vertebrates as models for human development and disease mechanisms Development of in-vivo imaging technologies for phenotyping and functional analysis in cells and animal models Recommended topics from the EoIs

14 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP RNA interference screening in Arabidopsis for identification of gene functions relevant to health Molecular tools for phenotyping human populations Coordination and standardisation of high throughput genotyping in human populations in Europe Standardisation and integration of genomic and phenotypic information on bacterial diversity linked to human health Recommended topics from the EoIs Comparative genomics and population genetics

15 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Bioinformatics Developing methods and resources in bioinformatics to focus on human genome annotation Bioinformatics and genomics grid for European research Development of an integrated software platform to tackle genomic sequence-structure-function relationships Recommended topics from the EoIs

16 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Basic biological processes Multidisciplinary approaches of functional genomics for : The cell cycle Non-human embryonic stem cell differentiation Erythroid development and disorders Lymphangiogenesis Epigenetics: chromatin dynamics, non-coding RNA, imprinting and silencing Inflammation processes in human disease Ubiquitin-proteasome and related pathways Recommended topics from the EoIs

17 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Multidisciplinary approaches of functional genomics for : Animal models for studying human kidney disease Peroxisomes in health and disease Inner ear or retina development and disorders DNA damage and repair mechanisms in health and disease Animal models to study human disease of the immune system or muscle Large epidemiological studies of X-linked syndromes Basic biological processes Recommended topics from the EoIs

18 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Indicative topics for STREPs and CA Standardisation of gene expression DNA arrays and proteomics approaches Deciphering the processes underlying the controlled integration and expression of transgenes in model organisms Methods for the production of crystals for high throughput structural determination Transposon mutagenesis methods in the mouse Co-ordination of functional genomics in the rat model Role of non-coding RNA in disease Molecular systems biology approaches for modelling gene functions and complex regulatory networks

19 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Detecting low abundance mRNAs and proteins Identifying new multi-protein nanomachines Comparative genomics in protozoa relating to human health Programmed cell death across the eukaryotic kingdom Compiling large data sets on splice variants in humans Signal transduction pathways mediated via serine/threonine kinases Indicative topics for STREPs and CA

20 LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH FP Workshops on structuring research activities of fundamental genomics in important fields not yet addressed Workshops on business opportunities in functional genomics Bilateral meetings on fundamental genomics issues between scientists from Europe and a third country having an S&T co- operation agreement with the EU Meetings on integration of candidate countries' researchers in specific activity lines to be supported under this part of the programme Technology foresight meetings to identify future opportunities within the field of functional genomics Indicative topics for SSA


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