Presentation on theme: "Ecstasy Damages Brain Serotonin Neurons Presented by Michelle Dupre Biology Department Eastern Connecticut State University."— Presentation transcript:
Ecstasy Damages Brain Serotonin Neurons Presented by Michelle Dupre Biology Department Eastern Connecticut State University
Positron emission tomographic evidence of toxic effect of MDMA (Ecstasy) on brain serotonin neurons in human beings. Article written by: U.D McCann, Z. Szabo, U. Scheffel, R. F. Dannals, G. A. Ricaurte The Lancet :
What do we know about Ecstasy?
Transport of serotonin
Previous findings… Animals show losses in serotonin markers Doses parellel human doses Previous studies use cerebrospinal fluid
Positron Emission Tomography (PET) Detects status of neurons in the brain Attaches to face masks 11 C Labels serotonin transporter Neuroimaging technique
The Experiment Experimental group Control group PET scanning
What were they looking for? 1) Differences in serotonin transport sites. 2) The relationship between MDMA use and binding. 3) Overall brain activity
MDMA users have lower densities of 5-HT transporter sites. Direct relationship between MDMA use and decrease in 5-HT binding.