Presentation on theme: "Genesis of Cardiac Arrhythmias Mike Hansen Biology Department Eastern CT State University."— Presentation transcript:
Genesis of Cardiac Arrhythmias Mike Hansen Biology Department Eastern CT State University
Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias The Journal of Biological Chemistry Vol. 276, pp. 28,197-28,2003 C. A. Ufret-Vincenty, D. J. Baro, W. J. Lederer, H. A. Rockman, L. E. Quinones, and L. F. Santana University of Puerto Rico, University of Maryland School of Medicine, and Duke University Medical Center
Cardiac arrhythmias Leading cause of death in patients with HF Contractile dysfunction Possibly due to prolonged AP: Change in ion currents and Ca+ signaling Is it deglycosylation? ?
Methods Used a mouse as a model for HF It lacked expression of MLP Compared with normal heart
Ventricular myocytes ECG measurements Single cell a.p.
Ion channels Ion channels in cell membrane Receive signal to open Influx of sodium ions