Antibiotics - Introduction Selective toxicity - kills or stops growth of bacteria w/o damaging the host (human body) Bacteria - unicellular microorganisms - must rely on host for nourishment –Most harmful –Some needed effects Most bacteria destroyed by immune system
Antibiotics - Types Broad Spectrum - useful on a wide variety of bacteria Narrow Spectrum - useful on only a few varieties of bacteria
Antibiotics - Mechanism of Action 1. Inhibit cell wall synthesis & function –decrease rigidity of cell wall - cause it to burst Examples –(Penicillin) –(Amoxicillin) –(Cephalosporins, Cephalexin) Keflex –Bacitracin **high occurrence of allergic reactions
Antibiotics - Mechanism of Action 2. Inhibits protein synthesis by attaching to ribosomes –kills bacteria or slows growth Examples –(Tetracycline) –(Erythromycin) –(Azithromycin) Z-pack, Zithromax
Antibiotics - Mechanism of Action 3. Inhibit bacterial DNA/RNA synthesis –affects structure, function, & synthesis of DNA - cant reproduce Examples –(Ciproflaxin) Cipro –(Sulfadiazine) Silvadene –(Sulfa)
Resistance to Antibiotic Drugs Bacteria develop natural or acquired resistance to antibiotics - allows bacteria to survive What can be done????
Antiviral Virus – intracellular parasites, lack cell wall & cell membranes; dont have metabolic processes Antiviral medicines treat Influenza A & B and RSV Examples: –(Famiclor) Famvir –(Zanamivir) Relenza –(Oseltamivir phosphate) Tamiflu