2Antibiotics - Introduction Selective toxicity - kills or stops growth of bacteria w/o damaging the host (human body)Bacteria - unicellular microorganisms - must rely on host for nourishmentMost harmfulSome needed effectsMost bacteria destroyed by immune system
3Antibiotics - TypesBroad Spectrum - useful on a wide variety of bacteriaNarrow Spectrum - useful on only a few varieties of bacteria
4Antibiotics - Mechanism of Action 1. Inhibit cell wall synthesis & functiondecrease rigidity of cell wall - cause it to burstExamples(Penicillin)(Amoxicillin)(Cephalosporins, Cephalexin) KeflexBacitracin**high occurrence of allergic reactions
5Antibiotics - Mechanism of Action 2. Inhibits protein synthesis by attaching to ribosomeskills bacteria or slows growthExamples(Tetracycline)(Erythromycin)(Azithromycin) Z-pack, Zithromax
6Antibiotics - Mechanism of Action 3. Inhibit bacterial DNA/RNA synthesisaffects structure, function, & synthesis of DNA - can’t reproduceExamples(Ciproflaxin) Cipro(Sulfadiazine) Silvadene(Sulfa)
7Resistance to Antibiotic Drugs Bacteria develop natural or acquired resistance to antibiotics - allows bacteria to surviveWhat can be done????
8AntiviralVirus – intracellular parasites, lack cell wall & cell membranes; don’t have metabolic processesAntiviral medicines treat Influenza A & B and RSVExamples:(Famiclor) Famvir(Zanamivir) Relenza(Oseltamivir phosphate) Tamiflu