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Gastrointestinal Drugs. Antacids Neutralize stomach acids - cause of heartburn Active ingredients - aluminum, magnesium hydroxide, calcium carbonate,

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Presentation on theme: "Gastrointestinal Drugs. Antacids Neutralize stomach acids - cause of heartburn Active ingredients - aluminum, magnesium hydroxide, calcium carbonate,"— Presentation transcript:

1 Gastrointestinal Drugs

2 Antacids Neutralize stomach acids - cause of heartburn Active ingredients - aluminum, magnesium hydroxide, calcium carbonate, sodium bicarbonate Bases combine w/ acid to pH Examples –Tums –Maalox, Mylanta –Pepto-Bismal

3 Antacids Adverse effects - constipation, diarrhea Acid Rebound Phenomenon

4 Histamine (H 2 ) Blockers (Acid Reducers) Presence of histamine cause the release of gastric acids in stomach Action - prevent (limit) release of histamine by blocking receptor sites Indications –acute & chronic ulcers –stomach pain –GERD

5 H 2 Blockers Examples –Tagamet (Cimetidine) –Pepcid AC (Famotidine) –Zantac 75 (Rantidine) –Prilosec – blocks action of H+/K+ ATPase proton pump which secretes acid into the stomach –Nexium – new med to treat erosion of esophagus *** Antacids & H 2 Blockers should not be a panacea for poor eating habits

6 Antidiarrheal Actions –slow peristalsis –adsorbent (absorb H 2 O & electrolytes) Examples –Immodium AD (Loperamide) –Donnagel, Kaopectate –Pepto-Bismal - antibacterial effects

7 Antiemetics Action - decrease nausea & vomiting –various receptors in CNS to suppress nausea –coat the stomach & decrease irritation Examples –Phenergan (Promethazine HCl) –Benedryl (Diphenhydramine) –Dramamine (Dimehydinate) –Emetrol - Dextrose, Fructose, Phosphoric Acid –Marinol ????

8 Laxatives Examples –Citracel –Metamucil –Correctol –Milk of Magnesia Drs. recommend non-medicinal remedies Illegal in sports!


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