1. Data Access Pilot Project (DAPP) Mei-Hua Huang, DrPH Sharon Stein Merkin, PhD Core Directors: Gail Greendale, MD, Arun Karlamangla, PhD, MD Teresa Seema, PhD DAPP Faculty: Mei-Hua Huang, DrPH Sharon Stein Merkin, PhD Weijuan Han, MS Funded by the Older Americans Independence Center (OAIC)

2. Why DAPP?

3.  Personal Data Shopper  Tailor to your study needs  How do you get your data?  Guidance/advice  Efficiency

4. Introductions to DAPP Faculty  Mei-Hua Huang, DrPH, Nutritional Epidemiology Nutritional Epidemiology  Sharon Stein Merkin, PhD, Social Epidemiology Social Epidemiology

6. Study Implementation Study Hypothesis DataStudy Design Analysis Publication

7. Example using Public Data- NHANES Is education associated with awareness, treatment and control of hypertension? DATA Potential overlap in the literature Obtain data weighting/survey design issues unique to NHANES STUDY DESIGN Cross sectional Multiple waves? Defining exposure and outcome Analysis plan Analysis Publication

8. Example of Data Requiring Proposal - SWAN Study Hypothesis DataStudy Design Analysis Publication Potential overlap Request data access Submit concept proposal to publication committee Analysis Abstract, poster and manuscript submitted to publication committee Time consuming: minimum months

9. Services of DAPP Research guidance/consulting  Guidance in implementing study hypotheses  Identifying relevant datasets  Assistance with data access  Available online Public data (e.g., NHANES) Public data (e.g., NHANES) Non-public (e.g., SWAN) Non-public (e.g., SWAN)  Request to Study PI (e.g., PEPI)  Guidance in navigating datasets  Contacts  Analysis services* *Minimal, potential analyst time depending on funding

10. Dataset List Study Study Design Study of Women's Health Across the Nation (SWAN) Longitudinal cohort Postmenopausal Estrogen/Progestin Interventions (PEPI) Clinical trial Osteoporotic Fractures in Men (MrOS) Study Longitudinal cohort Study of Osteoporotic Fractures (SOF) Longitudinal cohort Rancho Bernardo Study Longitudinal cohort Yoga Empowers Seniors Study (YESS) Clinical trial Yoga for Kyphosis Trial Clinical trial

11. Dataset List Study Study Design National Health and Nutrition Examination Survey (NHANES) Cross-sectional Multiethnic Study of Atherosclerosis (MESA) Longitudinal cohort Midlife in the United States (MIDUS) Longitudinal cohort Coronary Artery Disease Risk Development in Young Adults (CARDIA) Study Longitudinal cohort Atherosclerosis Risk in Communities (ARIC) Study Longitudinal cohort Cardiovascular Health Study (CHS) Longitudinal cohort Health and Retirement Study (HRS) Longitudinal cohort

12. MIDUS: Midlife in the United States   Longitudinal cohort study   Main objective: psychosocial, behavioral, sociodemographic correlates with aging   n=7108; ages 24-74 years   MIDUS 1: White (88%), AA (6%), Other (6%)   MIDUS 2: White (80%), AA (15%), Other (5%)   2 visits   MIDUS 1: 1994-1995; MIDUS 2: 2005-2006 (including new Milwaukee participants)   Recruited from across the U.S.   Access: public, download from ICPSR website

13. MIDUS: Midlife in the United States MIDUS 1MIDUS II Project 1n=7108 Phone/SAQ Demographics, Psychosocial, Medical history n=5555 Phone/SAQ Demographics, Psychosocial, Medical history Project 2Daily Diary n=2022 Project 3Cognition n=4518 Project 4Biomarkers n=1255

14. CHS: Cardiovascular Health Study   Longitudinal cohort study   Main objective: study determinants of cardiovascular disease   n=5888; ages 65+ years; White (81%) AA (16%) Other (3%)   10 exams   Baseline: 1989; yearly follow-up through 1999.   AA cohort initiated study in 1992   Recruited from 4 US communities   Access: proposal and approval from CHS

15. CHS: Cardiovascular Health Study Baseyr3yr4yr5yr6yr7yr8yr9yr10yr11 Self-rated health xxxxxxxxxX Educationx Incomexxxx Depressionxxxxxxxxxx Phlebotomyxxxxx Nutritionxx AA cohort

16. ARIC: Atherosclerosis Risk in Communities   Longitudinal cohort study   Main objective: investigate the cause of atherosclerosis and its clinical outcomes   n=15,792; ages 45-64 years; White (73%) Non-White (27%) 5 visits   Baseline: 1987-1989; Visit 2: 1990-1992; Visit 3: 1993-1995; Visit 4: 1996-1998; Visit 5: 2009-2011   Recruited from 4 US communities   Access: proposal and approval from ARIC

17. ARIC: Atherosclerosis Risk in Communities

18. CARDIA: Coronary Artery Risk in Young Adults   Longitudinal cohort study   Main objective: study determinants of subclinical cardiovascular disease   n=5115; ages 18-30 years; White (50%) AA (50%)   8 visits   Baseline: 1985-1986, Visit 2: 1987-88, Visit 3: 1990- 91, Visit 4: 1992-93, Visit 5: 1995-96, Visit 6: 2000-01, Visit 7: 2005-6, Visit 8: 2010-11   Recruited from 4 US communities   Access: proposal and approval from CARDIA

19. CARDIA: Coronary Artery Risk in Young Adults

20. MESA: Multi-Ethnic Study of Atherosclerosis   Longitudinal cohort study   Main objective: study determinants of subclinical cardiovascular disease   n=6814; ages 45-84 years; White (38%) AA (28%) Chinese (12%) and Hispanic (22%)   5 exams   Baseline: 2000-2002; Exam 2: 2002-2004; Exam 3: 2004-2005; Exam 4: 2005-2007; Exam 5: 2010-2012   Recruited from 6 US communities   Access: proposal and approval from MESA

21. MESA: Multi-Ethnic Study of Atherosclerosis Exam 1Exam 2Exam 3Exam 4Exam 5 N=6814N=6232N=5939N=5704N=4651 Personal/ Medical Hx/ Psychosocial XXXXX Family HxX Sleep HxXX A 2500 Residential/neighborhoodX Occupation/employmentXXX Physical ActivityXXXX Food Frequency (Diet)XX AnthropometryXXXXX Phlebotomy collectionXXXXX Urine collectionXXXX GenotypingX Cognitive FunctionX

22. Study of Women’s Health Across the Nation (SWAN)  Multi-center, multi-ethnic, community based longitudinal study  Characterize the biological, symptomatic, and psychosocial changes that occur during the MT  Understand the effects of these changes on women's health during and after the MT

23. SWAN Overview: Cohort Eligibility  aged 42-52 years  at least 1 menstrual period in prior 3 mo  a member of each site's racial/ethnic group Participants 3,302 women at 7 clinical sites  1550 Caucasian [all sites]  935 African American [Chicago, Pittsburgh, Boston, Detroit]  286 Hispanic [NJ]  250 Chinese [Davis]  281 Japanese [LA]

24. SWAN Overview: Data Collection Schedule

31. SWAN Ancillary Studies   Fat Patterning (Diabetes Risk)   Functional Status   Hip Strength   Mammographic Density   Mental Health   Phytoestrogens   Sleep   Subclincial Atherosclerosis (SWAN Heart)

32. How to get started using DAPP   Contact : Dr. Huang (mhuang@mednet.ucla.edu) or Dr. Merkin (smerkin@mednet.ucla.edu)mhuang@mednet.ucla.edusmerkin@mednet.ucla.edu   Dataset Information http://geronet.ucla.edu/dapp http://geronet.ucla.edu/dapp   Complete a pre-consultation survey