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Table of Ka Values Acid-Dissociation Constants of Representative Alcohols Alcohol Structure KapKa methanol ethanol 2-chloroethanol 2-2-trichloroethanol.

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Presentation on theme: "Table of Ka Values Acid-Dissociation Constants of Representative Alcohols Alcohol Structure KapKa methanol ethanol 2-chloroethanol 2-2-trichloroethanol."— Presentation transcript:

1 Table of Ka Values Acid-Dissociation Constants of Representative Alcohols Alcohol Structure KapKa methanol ethanol 2-chloroethanol 2-2-trichloroethanol isopropyl alcohol t-butyl alcohol phenol cyelohexanol water acetic acid hydrocholric acid Comparison with other acids

2 METHODS FOR THE SYNTHESIS OF ALCOHOLS (to date)

3 ELECTROPHILIC AND NUCLEOPHIC CARBON Methylmagnesium bromideMethyl lithium Methyl chloride

4 TYPICAL ELECTROPHILES acetone Methyl chloride

5 Alcohols, carbonyl compounds and carboxylic acids: REDUCTION Reduction: Addition of H2 (or H-), loss of O or O2; loss of X2 Aldehyde Carboxylic acidPrimary alcohol KetoneSecondary alcohol Teritiary alcohol Lithium aluminium hydride Sodium borohydride must convert OH to leaving group must convert OH to leaving group

6 Comparison of Reducing Agents LiAlH4 reduces more stable compounds which are resistant to reduction. LiAlH4 is stronger. reduces ester Acid (anion) aldehyde ketone ease of reduction

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