Presentation is loading. Please wait.

Presentation is loading. Please wait.

1 A Design of a Molecular Communication System Using Biological Communication Mechanisms T. Nakano*, A. Enomoto*, M. Moore*, R. Egashira*, T. Suda*, K.

Similar presentations


Presentation on theme: "1 A Design of a Molecular Communication System Using Biological Communication Mechanisms T. Nakano*, A. Enomoto*, M. Moore*, R. Egashira*, T. Suda*, K."— Presentation transcript:

1 1 A Design of a Molecular Communication System Using Biological Communication Mechanisms T. Nakano*, A. Enomoto*, M. Moore*, R. Egashira*, T. Suda*, K. Oiwa +, Y. Hiraoka +, T. Haraguchi +, R. Nakamori +, T. Koujin + *University of California, Irvine + National Institute of Information and Communications Technology

2 2 Outline Nanomachine communication Nanomachines Our approach Molecular communication Example systems Conclusions

3 3 Nanomachine Communication Goal Achieve communication between nanomachines Nanomachine: nano-scale or molecular scale objects that are capable of performing simple tasks Figure: Protonic Nanomachin Project, Prof. Namba at Osaka University:

4 4 Nanomachines Biological nanomachines Dynein Molecular motors that walk along microtubule in a cell F1ATPase Synthesizes ATP (energy) by using an influx of protons to rotate Bacterium Swims toward the chemicals (e.g, food) using flagellum Figures: Alberts, Molecular Biology of the Cell Dynein F1ATPase Bacterium

5 5 Nanomachines Biological nanomachines logic gates made of biological components (e.g, enzymes or bacteria) If both substrate and effector exist, product produced If no effector or no substrate, substrate remains unchanged AND C S P Enzyme Product Substrate Effector

6 6 Nanomachines Artificial nanomachines Nickel propeller Size: um Micron motor Size: 100 um in diameter 10,000 rpm MEMS/NEMS: Engineering Issues in the fabrication of a hybrid nano-propeller system powered by F1-ATPase

7 7 Our Approach Use communication mechanisms that biological systems use Intracellular communication Intercellular communication

8 8 Intracellular Communication Transport materials using molecular motors within a cell Vesicles transported by molecular motors Microtubules

9 9 Cells coordinate through calcium signaling J. Cell Biol. Jørgensen et al. 139 (2): 497, Intercellular communication

10 10 Applications Pinpoint drug delivery To deliver drug to (targeted) cancer cells Molecular computing Coordination among distributed logical gates AND OR AND C S P Enzyme Product Substrate Effector

11 11 Outline Nanomachine communication Nanomachines Our approach Molecular communication Example systems Conclusions

12 12 Molecular Communication Sending and receiving of molecules as an information carrier

13 13 Make nanomachines communicate using communication mechanisms in living organisms Senders/receivers = biological nanomachines Communication carrier = molecules (e.g., proteins, ions, DNAs) Communication distance = nano/micro scale A receiver (chemically/physically) reacts to incoming molecules

14 14 Receivers (nanomachines) Senders (nanomachines) Information molecules (Proteins, ions, DNA) 1. Encoding 2. Sending 3. Propagation 4. Receiving 5. Decoding

15 15 Key System Components A sender Molecule generation Molecule encoding Molecule emission Propagation Molecule loading at a sender Direction control Molecule unloading at a receiver Molecule recycling

16 16 A receiver Molecule reception Molecule decoding Molecule decomposition or recycling

17 17 System Characteristics We want the system to be Autonomous (i.e., no human control) Closed (i.e., no energy supply from outside) Recycling (of carrier molecules and information molecules) Other system characteristics Probabilistic behavior Many to many communication Slow delivery of molecules

18 18 Two Example Systems Molecular Communication Using a cellular network Using molecular motors

19 19 Network of Biological Cells Amplifier Switch Engineering the network components using cells Encoding information on calcium waves Decoding information from calcium waves Various cellular responses (e.g., contraction, secretion, growth, death) Example 1: Molecular Communication Based on a Cellular Network

20 1-n communication (broadcasting medium)

21 1-1 communication

22 22 Nanoscale protein channels connecting two adjacent cells Allowing small molecules to be shared among cells, enabling coordinated action of the cells Gap Junctions

23 23 Example Networking Filtering signals Signal X is more permeable to channels formed between the cells

24 24 Example Networking Filtering signals Signal Y is more permeable to channels formed between the cells

25 25 Example Networking Switching the direction of signaling External signal

26 26 Example Networking Switching the direction of signaling Phosphorylation of channels increases/decreases permeability of the channels.

27 27 Nanomachines communicate using molecular motors. Molecules are transported by molecular motors that walk over a network of rail molecules. Example 2: Molecular Communication Using Molecular Motors

28 28 Outline Nanomachine communication Nanomachines Our approach Molecular communication Example systems Conclusions

29 29 Research Issues Developing applications that require communication among bio nanomachines System designs using biological communication mechanisms Autonomous, closed, recycling system Various system components Creating new information and coding concepts and models Various approaches Feasibility test through experiments Theoretical modeling and analysis Simulations

30 30 Conclusions Molecular Communication New paradigm Need a lot of research Integrating nano technology, bio technology and computer science


Download ppt "1 A Design of a Molecular Communication System Using Biological Communication Mechanisms T. Nakano*, A. Enomoto*, M. Moore*, R. Egashira*, T. Suda*, K."

Similar presentations


Ads by Google