1. January 27, 2009 4 th BVDV Symposium –BVDV Variability: Impact on Virulence, Host Range, and Control Bovine Viral Diarrhea Virus (BVDV) Research Needs and Coordinating Efforts of NCBA, AABP, AVC, and USAHA

2. BVDV Research Priorities: Input NCBA BVD Research Subcommittee 2008 NCBA BVD Working Group 2008 Academy of Veterinary Consultants: BVDV committee AABP BVDV committee 2008 USAHA Infectious Diseases of Cattle Committee

3. Priority Item Knowledge Gap Approach Deliverable

4. BVDV Research Priorities 1. Assessment of the Economic Impact of BVDV in Beef Production Operations 2. Design and Evaluation of Surveillance/Control Programs 3. Surveillance, Identification, and Determination of Significance of Emerging BVDV Subtypes 4. Development and Critical Evaluation of Diagnostic Tests 5. Critical Evaluation of Current Vaccines 6. Development of Innovative New BVDV Vaccines 7. Investigate the Pathogenesis of BVDV in Cattle Based on Disease Predisposition and Genetics

5. BVDV Research Priorities Assessment of Economic Impact of BVD in Beef Production Operations General economic impact of BVD Transmission dynamics of PI (Persistently Infected) and TI (Transiently Infected) BVD cattle in production enterprises in relation to economic cost Morbidity and mortality rate of TI and PI calves in relation to economic cost

6. Design and Evaluation of Surveillance Programs Surveillance strategies for early detection of PI BVDV incursion in BVDV negative beef breeding herds and support for herd disease freedom claims Testing strategies at the ranch, dairy, auction market or feedyard to economically detect positive individuals and herds and to control herd introduction risk Management strategies for biosecurity and biocontainment to control impact of PI cattle Role of wildlife as reservoir of exposure and infection for cattle

7. Surveillance, Identification, and Determination of Significance of Emerging BVDV Subtypes Detection and confirmation of new BVDV subtypes in the U.S. Determine if differences among BVDV subtypes affect diagnostic and vaccine performance.

8. Development and Critical Evaluation of Diagnostic Tests Validation of diagnostic tests available in the U.S. Innovative test development

9. Critical Evaluation of Current Vaccines Fetal protection challenge studies for all USDA licensed vaccines Effective models for acute challenge for the postnatal susceptible calf Duration of immunity after BVDV vaccination

10. Development of Innovative New BVDV Vaccines Novel vaccines Marker vaccines Adjuvants

11. Investigate the Pathogenesis of BVDV in Cattle Based on Disease Predisposition and Genetics Genetics for infectious disease resistance/susceptibility relating to BVDV

12. Critical Issues Facing BVDV Programs and Various Groups Definition and agreement on goals of control and eradication Adequate funding at federal- state levels Private and corporate, producer organizations Collaborative research teams Unified voice on control programs to the producers Numerous groups already involved Potential of a national committee with range of participants