1. Personal Genetics A Self-Discovery Platform

2. © 23andMe, Inc.2 Personal Genetics--Why Now? People want to know Information is empowering Genetics research + community = more power Whole genome sequencing is coming Education is key

3. © 23andMe, Inc.3 Personal Genome Service Launched Nov 2007 ~600K genotypes generated per customer From 14 to over 100 reports –Research Reports/Clinical Reports Added survey tools Added community feature –Over 1000 conversation threads Moved to second generation array Launched research platform (23andWe)

4. © 23andMe, Inc.4 v2 Custom Content Ancestry markers (Y and Mito coverage) DMET for PGx-focused studies Rare mutations for carrier status –BRCA, LRRK2, Cystic Fibrosis, etc. HLA coverage for immune system SNPs of interest published in recent GWAS studies Launched research platform (23andWe)

5. © 23andMe, Inc.5 Genomic Cloud Computing

6. © 23andMe, Inc.6 Genome Canvas

7. © 23andMe, Inc.7

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9. 9 Mother/Child

10. © 23andMe, Inc.10 Identical Half-identical Different Siblings

11. Health and Traits

12. © 23andMe, Inc.12

13. © 23andMe, Inc.13 Crohns Disease Risk

14. © 23andMe, Inc.14 Crohns Disease Risk

15. © 23andMe, Inc.15 Crohns Disease (50-60% Genetics Risk)

16. Personal Genetics A Research Platform

17. © 23andMe, Inc.17

18. © 23andMe, Inc.18 23andWe Surveys

19. © 23andMe, Inc.19 Parkinsons Study

20. Personal Genetics A Translational Platform

21. © 23andMe, Inc.21 New: Warfarin PGx Report Goal: Build large community of patients on warfarin, track INRs, develop evidence base for genetic data, find additional markers.

22. © 23andMe, Inc.22 PGSPHR Research Data EMR Healthcare Consumer CliniciansHospitals Validated Data Testing Labs Patient-Centric Health Data