Presentation on theme: "Taking Research and Development To The Clinic… Are We There Yet?"— Presentation transcript:
1 Taking Research and Development To The Clinic… Are We There Yet? Paula Kim , TRAC- Translating Research Across CommunitiesAAAS-FDLI Personalized Medicine: Planning for the FutureColloquium 1: Diagnostics and Diagnoses: Paths to Personalized MedicineWashington DC • June 1, 2009
2 The Art of Translation… “ From the standpoint of medicine as an art for the preparation and cure of disease, the man who translates the hieroglyphics of science into the plain language of healing is certainly more useful.”-Sir William Osler, Physician
3 Across The Scientific Spectrum PhysicalBehavioralSocialCulturalEconomicPoliticalSpiritualTechnological
5 For Our Road Trip… How Do We Describe Personalized Medicine? JourneyDestinationVehicleHighwayRoad MapCompass
6 Patient Dilemma with Words and Decisions… Personalized medicine?Donate tissue?Biospecimen?Biopsy? 2nd pass?Targeted Therapies?Genomics? Proteomics?Invasive ? Non-invasive?Academic Center ? Local ?Informed Consent?How to pick treatment?Do my kids need genetic testing?Where is my tissue?Eligible ? Insurance ?Am I Going to Live?
7 The Promise Personal Targeted Therapies Seek and Control instead of Search and DestroyGenetic TestingReduced ToxicitiesPredictive/Preventive CapabilityReduced drug failure ratesA CUREHype or Not?
9 Hide and Seek? Currently… No coordinated system to assist patients Many patients with difficult to treat disease have poor prognosis, limited options, and a very short timeframe to make decisions; lack access to internetPatients and caregivers often receive very little direction & guidance for treatment, system navigation and financial options
10 Treatment Decision Making: Outside Sources of Info for Patients Answer OptionsGreatlyinfluencesSomewhatBarelyDoes notinfluenceNotapplicableInformation received from a patient advocacy organization156319711Information read in the newspaper or mainstream magazine537352710Information heard on the TV or radio12041Information retrieved on the internet602598Source: TRAC Perspectives on Costs of Cancer Care Survey-2006
11 Understanding Choices In Order To Make Decisions: What Patients Want Source: TRAC Perspectives on Costs of Cancer Care Survey-2006
12 The Law and Spice of Life “Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions which we know as disease.”-Sir William Osler, Physician
13 Hide and Seek… …Olly Olly Oxen Free Ready or not, personalized medicine is moving… towards becoming the norm and not the exception…How fast we get there…will depend on many factors with perhaps two of the most important ones being the access and use of high quality well annotated biospecimens… and how well or not everyone… behaves along the way.
15 Challenges and Questions That Will Arise Do We Have a National SystemWill It Level the Playing Field or NotWill Access Be More Inclusive or ExclusiveHow Does This Affect Me and My FamilyJust Because You Build It, Does Not Mean They Will Come
16 Why We Must Get This Right… “ We must harness the scientific, industrial, and social will to accelerate discoveries into accessible and meaningful clinical applications. Patients, families, friends, and loved one are counting on us…Because in the end, it’s not about you, or me, or the science, it’s about the patient.”Paula Kim - Research & Patient Advocate
17 Patient & Advocate Perspectives Don’t Leave Home Without Them