1. 3D Slicer for Image Guided Therapy Program Goal: To develop general display, control, and communications modules providing a resource to support diverse IGT applications –Thermal therapies –Vascular interventions –Surgical excision Specific Aim: Provide seemless tracking for rigid tools and catheters inside and outside of MRI scanner. Enable –Dynamic Volume Acquisition –Continuous 3D Visualization –Real-time MR System Control

2. Tracking Systems GE InstatrakEM Tip TrackingMRI NDI PolarisPassive optical, hybrid AuroraEM IGT FlashpointActive optical Robin Medical EndoscoutEM / MRI gradient Biosense Webster CARTOEM / induction coil Ascension Bird, MicrobirdEM

3. Slaving of 3D Slicer Workstation Read coordinates from FDA approved system (e.g., GE Navs). FDA approved system provides primary source of information to clinician 3D Slicer provides augmented information (e.g., DTI) and will serve as a research platform.

4. Platforms 3D Slicer Pai Saiveroonporn – Thermal mapping, on-line scanner control Ryoichi (under Zientara grant) – Cryo iceball prediction Eigil Samset – Oslo Randy Ellis – Queens College Mike Guttmann - NIH

5. Interactive Scanner Control Dynamic re-sizing, re-orienting and re-positioning for rapid targeting of treated volume

6. 1st Qtr2nd Qtr 0 50 100 1st Qtr2nd Qtr Control Console Multi-computer MRI Scanner System Adaptive Scanner Control Dynamic re-ordering and reshaping of acquisition for rapid adaptation to changes in treated volume

7. Flexible protocol definition to serve diverse IGT applications Temperature Visualization adjustment

8. Multi-planar views of treatment evolution: real-time or retrospective Anatomical Temperature Thermal Dose movie

9. Real-time rendering of treatment volume movie Temperature Thermal Dose TemperatureThermal Dose

10. Real-time Surface Visualization movie Temperature Thermal Dose TemperatureThermal Dose

11. Cryotherapy (Zientara) Intra-procedural 3D Assessment Real-time Monitoring and Controlling

12. CRYOTHERAPY – RENAL 3) Monitoring 4) Controlling 2nd 15 min Freeze

15. Real-time Control of 3D-Slicer Visualization using Coordinates from Electrophysiological Catheter Tracking System (Westin)

16. Reformatted view of the MRI volume using the location and orientation of the CARTO points.

17. Microscope/endoscope video registration to MR/CT Simon Warfield P01 Lighthouse Imaging SBIR, CIMIT

18. A Navigation System for Augmenting Laparoscopic Ultrasound (Ellsmere)

19. Neuro intervention (Pujol) Ascension microbird integrated into Slicer

20. Open tracker www.studierstube.org/opentracker Developed by Technical University of Graz flexible XML based tracking framework source code available under for Windows, Irix and Linux. includes drivers for a range of different tracking systems. modules for some addition tracking systems have been developed by Samset et al. can be used to maintain registration across different tracking systems