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Contact inhibition of locomotion probabilities drive solitary versus collective cell migration by Ravi A. Desai, Smitha B. Gopal, Sophia Chen, and Christopher.

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Presentation on theme: "Contact inhibition of locomotion probabilities drive solitary versus collective cell migration by Ravi A. Desai, Smitha B. Gopal, Sophia Chen, and Christopher."— Presentation transcript:

1 Contact inhibition of locomotion probabilities drive solitary versus collective cell migration by Ravi A. Desai, Smitha B. Gopal, Sophia Chen, and Christopher S. Chen Interface Volume 10(88):20130717 November 6, 2013 ©2013 by The Royal Society

2 Patterned culture reveals cell repolarization. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society

3 CIL is triggered upon head-to-head collision between cells. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society

4 CIL operates statistically independently. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society

5 Trains behave as a coherent unit, and repolarize in a length-dependent manner. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society

6 Collective, persistent trains of cells emerge from CIL between cells. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society

7 An agent-based model predicts the emergence of trains. Ravi A. Desai et al. J. R. Soc. Interface 2013;10:20130717 ©2013 by The Royal Society


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