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HEART TRANSPLANTATION Overall ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982.

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Presentation on theme: "HEART TRANSPLANTATION Overall ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982."— Presentation transcript:

1 HEART TRANSPLANTATION Overall ISHLT 2005 J Heart Lung Transplant 2005;24:

2 NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR ISHLT 2005 NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of hearts transplanted worldwide has declined in recent years. J Heart Lung Transplant 2005;24:

3 AVERAGE CENTER VOLUME Heart Transplants: January 1, June 30, 2004 ISHLT 2005 J Heart Lung Transplant 2005;24:

4 DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUME Heart Transplants: January 1, June 30, 2004 ISHLT 2005 J Heart Lung Transplant 2005;24:

5 HEART TRANSPLANTS: Donor Age by Year of Transplant ISHLT 2005 J Heart Lung Transplant 2005;24:

6 AGE DISTRIBUTION OF HEART RECIPIENTS (1/1982-6/2004) % of Trnsplants % of Transplants ISHLT 2005 J Heart Lung Transplant 2005;24:

7 AGE DISTRIBUTION OF HEART TRANSPLANT RECIPIENTS BY ERA P < ISHLT 2005 J Heart Lung Transplant 2005;24:

8 HEART TRANSPLANTATION Kaplan-Meier Survival (1/1982-6/2003) ISHLT 2005 N followed at longest time point: 25,908 J Heart Lung Transplant 2005;24:

9 HEART TRANSPLANTATION Adult Recipients ISHLT 2005 J Heart Lung Transplant 2005;24:

10 DIAGNOSIS IN ADULT HEART TRANSPLANTS ISHLT 2005 J Heart Lung Transplant 2005;24:

11 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: 1/1982 – 6/2003) Survival (%) ISHLT 2005 J Heart Lung Transplant 2005;24:

12 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: 1/1982-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

13 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: 1/1996-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

14 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival for Simultaneous Heart and Kidney Transplants Compared to Heart-Alone Transplants (Transplants: 1/1982-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

15 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival for Kidney after Heart Transplants Compared to Heart-Alone Transplants * (Transplants: 1/1982-6/2003) ISHLT 2005 * For comparison purposes, the heart-alone transplant cohort was limited to those transplants that had survived to the median time to kidney transplant for the kidney after heart transplant (8.0 years). ** Survival time since kidney transplant (transplant date not reported, only time point at which kidney transplant has already occurred) J Heart Lung Transplant 2005;24:

16 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival for Kidney after Heart Transplants Compared to Kidney after Simultaneous Heart and Kidney Transplants (Transplants: 1/1982-6/2003) ISHLT 2005 * Survival time since kidney transplant (transplant date not reported, only time point at which kidney transplant has already occurred) J Heart Lung Transplant 2005;24:

17 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1982-6/2003) All pair-wise comparisons with Cardiomyopathy are significant at p < 0.05 except for Congenital; Coronary Artery Disease vs. ReTx: p < ; Coronary Artery Disease vs. Valvular: p = 0.02; Valvular vs. ReTx: p < ; Congenital vs. ReTx: p < ; ReTx vs. Other: p < ISHLT 2005 J Heart Lung Transplant 2005;24:

18 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis Conditional on Survival to 1 Year (Transplants: 1/1982-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

19 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1996-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

20 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis Conditional on Survival to 1 Year (Transplants: 1/1996-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

21 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by PVR (Transplants: 1/2000-6/2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

22 ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by VAD usage (Transplants: 1/1999-6/2003) ISHLT 2005 Note: Only 32 transplants involving continuous flow devices and 33 with ECMO; too few to analyze. J Heart Lung Transplant 2005;24:

23 ADULT HEART RE-TRANSPLANTS 1-Year Survival ISHLT 2005 J Heart Lung Transplant 2005;24:

24 ADULT HEART RECIPIENTS Functional Status of Surviving Recipients (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

25 ADULT HEART RECIPIENTS Employment Status of Surviving Recipients (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

26 ADULT HEART RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

27 ADULT HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January 2001 – June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

28 ADULT HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

29 ADULT HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (Follow-ups: January June 2004) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2005 J Heart Lung Transplant 2005;24:

30 ADULT HEART RECIPIENTS Maintenance Immunosuppression at Time of 1 Year Follow-up NOTE: Different patients are analyzed in each time frame. ISHLT 2005 J Heart Lung Transplant 2005;24:

31 ADULT HEART RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up (Follow-ups: January June 2004) NOTES: Different patients are analyzed in Year 1 and Year 5. In the Year 1 cohort 77.5% of patients were on prednisone; in the Year 5 cohort 62% of patients were on prednisone. ISHLT 2005 J Heart Lung Transplant 2005;24:

32 PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Type of Induction (Transplants: January 1, June 30, 2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

33 NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Type of Induction (Transplants: January 1, June 30, 2003) Overall: No induction vs. OKT3 (p = ); polyclonal vs. OKT3 (p=0.0065); IL2 vs. OKT3 (p=0.0004) : No induction vs. OKT3 (p = 0.006); polyclonal vs. OKT3 (p = 0.045); IL2 vs. OKT3 (p = 0.002) For females: no induction vs. OKT3 (p = 0.008) For males: polyclonal vs. OKT3 (p =0.04); IL2 vs. OKT3 (p = 0.003) ISHLT 2005 J Heart Lung Transplant 2005;24:

34 PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Maintenance Immunosuppression (Transplants: January 1, June 30, 2003) Overall: CyA + MMF vs. TAC + MMF (p<0.0001); CyA + MMF vs. TAC + AZA (p=0.02); CyA + AZA vs. TAC + MMF (p<0.0001); CyA + AZA vs. TAC + AZA (p=0.0056) : All comparisons significant except CyA + MMF vs. CyA + AZA : CyA + MMF vs. TAC + MMF (p=0.0001); CyA + AZA vs. TAC + MMF (p=0.004) : CyA + MMF vs. TAC + MMF (p<0.0001); CyA + AZA vs. TAC + MMF (p<0.0001). 65+: CyA + AZA vs. TAC + MMF (p=0.04). For females all comparisons are significant except TAC + MMF vs. TAC + AZA. For males: CyA + MMF vs. TAC + MMF (p<0.0001); CyA + AZA vs. TAC + MMF (p<0.0001) ISHLT 2005 J Heart Lung Transplant 2005;24:

35 NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Maintenance Immunosuppression (Transplants: January 1, June 30, 2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

36 POST-HEART TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors at 1 Year Post-Transplant (Follow-ups: April June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

37 POST-HEART TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors at 5 and 8 Years Post-Transplant (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

38 FREEDOM FROM CORONARY ARTERY VASCULOPATHY AND FREEDOM FROM SEVERE RENAL DYSFUNCTION* For Adult Heart Recipients (Follow-ups: April 1994-June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

39 FREEDOM FROM CORONARY ARTERY VASCULOPATHY Stratified by Diagnosis For Adult Heart Recipients (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

40 MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTS Cumulative Prevalence in Survivors (Follow-ups: April June 2004) Malignancy/Type1-Year Survivors 5-Year Survivors 8-Year Survivors No Malignancy17250 (96.9%)5753 (83.9%)1757 (73.8%) Malignancy (all types combined)544 (3.1%)1108 (16.1%)625 (26.2%) Malignancy Type Skin Lymph Other Type Not Reported Other includes: prostate (11, 34, 21), adenocarcinoma (7, 4, 2), lung (5, 4, 1), bladder (4, 5, 5), sarcoma (3, 3, 1), breast (2, 8, 3), cervical (2, 4, 0), colon (2, 3, 3), and renal (2, 7, 2). Numbers in parentheses are those reported within 1 year, 5 years and 8 years, respectively. ISHLT 2005 J Heart Lung Transplant 2005;24:

41 FREEDOM FROM MALIGNANCY For Adult Heart Recipients (Follow-ups: April June 2004) ISHLT 2005 J Heart Lung Transplant 2005;24:

42 ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January June 2004) CAUSE OF DEATH0-30 Days (N = 2,984) 31 Days - 1 Year (N = 2,523) >1 Year - 3 Years (N = 1,892) >3 Years - 5 Years (N = 1,631) >5 Years (N = 4,823) Coronary Artery Vasculopathy 47 (1.6%)117 (4.6%)271 (14.3%)275 (16.9%)719 (14.9%) ACUTE REJECTION 199 (67%)306 (12.1%)182 (9.6%)67 (4.1%)65 (1.3%) LYMPHOMA 2 (0.1%)48 (1.9%)81 (4.3%)86 (5.3%)221 (4.6%) MALIGNANCY, OTHER 2 (0.1%)52 (2.1%)196 (10.3%)299 (18.3%)883 (18.3%) CMV 4 (0.1%)31 (1.2%)15 (0.8%)3 (0.2%)5 (0.1%) INFECTION, NON-CMV 386 (12.9%)826 (32.7%)252 (13.3%)153 (9.4%)481 (10.0%) PRIMARY FAILURE 786 (26.3%)190 (7.5%)125 (6.6%)68 (4.2%)208 (4.3%) GRAFT FAILURE 416 (13.9%)263 (10.4%)314 (16.6%)236 (14.5%)668 (13.9%) TECHNICAL 220 (7.4%)28 (1.1%)15 (0.8%)17 (1.0%)44 (0.9%) OTHER 175 (5.9%)200 (7.9%)172 (9.1%)158 (9.7%)453 (9.4%) MULTIPLE ORGAN FAILURE 417 (14.0%)254 (10.1%)97 (5.1%)94 (5.8%)396 (8.2%) RENAL FAILURE 18 (0.6%)19 (0.8%)31 (1.6%)59 (3.6%)291 (6.0%) PULMONARY 122 (4.1%)85 (3.4%)85 (4.5%)62 (3.8%)189 (3.9%) CEREBROVASCULAR 190 (6.4%)104 (4.1%)61 (3.2%)54 (3.3%)200 (4.1%) ISHLT 2005 J Heart Lung Transplant 2005;24:

43 ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death from Leading Causes by Era (Deaths: January June 2004) CAUSE OF DEATH DATE OF DEATH 0-30 Days (N = 2,984) 31 Days - 1 Year (N = 2,523) >1 Year - 3 Years (N = 1,892) >3 Years - 5 Years (N = 1,631) >5 Years (N = 4,823) ACUTE REJECTION (6.9%)221 (13.8%)111 (9.2%)37 (4.0%)19 (1.2%) / (6.3%)85 (9.2%)71 (10.2%)30 (4.3%)49 (1.4%) CORONARY ARTERY VASCULOPATHY (1.7%)82 (5.1%)180 (15.0%)186 (20.1%)296 (18.6%) / (1.4%)35 (3.8%)91 (13.1%)89 (12.6%)423 (13.1%) GRAFT FAILURE (28.0%) 175 (11.0%)194 (16.1%)116 (12.5%)187 (11.7%) / (12.9%) 88 (9.5%)120 (17.3%)120 (17.0%)481 (14.9%) MALIGNANCY, OTHER (0.1%)38 (2.4%)116 (9.7%)177 (19.1%)281 (17.6%) / (1.5%)80 (11.5%)122 (17.3%)602 (18.6%) PRIMARY FAILURE (29.1%) 169 (10.6%)105 (8.7%)48 (5.2%)108 (6.8%) / (22.6%) 21 (2.3%)20 (2.9%)20 (2.8%)100 (3.1%) ISHLT 2005 J Heart Lung Transplant 2005;24:

44 ADULT HEART TRANSPLANT RECIPIENTS: Cumulative Incidence of Leading Causes of Death (Transplants: January June 2003) ISHLT 2005 J Heart Lung Transplant 2005;24:

45 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality 2005 ISHLT Note: All factors were significant at p < 0.05 in at least one of the eras. * Temporary circulatory support includes ECMO and Abiomed. **VAD type collected for only part of era. Only those with known type were included in this group. J Heart Lung Transplant 2005;24:

46 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality 2005 ISHLT Note: All factors were significant at p < 0.05 in at least one of the eras. J Heart Lung Transplant 2005;24:

47 ADULT HEART TRANSPLANTS (1/1996-6/2003) Borderline Significant Risk Factors for 1 Year Mortality 2005 ISHLT Note: All factors were significant at 0.5 < p < 0.1 in at least one of the eras. J Heart Lung Transplant 2005;24:

48 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality 2005 ISHLT J Heart Lung Transplant 2005;24:

49 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

50 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

51 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Pre-Transplant Recipient Weight 2005 ISHLT J Heart Lung Transplant 2005;24:

52 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

53 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Donor Weight/Recipient Weight 2005 ISHLT J Heart Lung Transplant 2005;24:

54 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Center Volume 2005 ISHLT J Heart Lung Transplant 2005;24:

55 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Ischemia Time 2005 ISHLT J Heart Lung Transplant 2005;24:

56 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Pre-Transplant Bilirubin 2005 ISHLT J Heart Lung Transplant 2005;24:

57 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Pre-Transplant Creatinine 2005 ISHLT J Heart Lung Transplant 2005;24:

58 ADULT HEART TRANSPLANTS (1/1996-6/2003) Risk Factors for 1 Year Mortality Recipient PA Diastolic Pressure 2005 ISHLT J Heart Lung Transplant 2005;24:

59 ADULT HEART TRANSPLANTS (1/196-6/2003) Factors Not Significant for 1 Year Mortality Recipient Factors: Pneumothorax, sternotomy, thoracotomy, ventricular remodeling, pregnancy, pulmonary embolism, prior malignancy, pulmonary vascular resistance, PCW, PA systolic Donor Factors: Clinical infection, history of diabetes, height, history of hypertension Transplant Factors: ABO identical/compatible 2005 ISHLT J Heart Lung Transplant 2005;24:

60 ADULT HEART TRANSPLANTS (1/1995-6/2003) 1-Year Predicted Survival – Hypothetical Patient 1 ISHLT 2005 J Heart Lung Transplant 2005;24:

61 ADULT HEART TRANSPLANTS (1/1995-6/2003) 1-Year Predicted Survival – Hypothetical Patient 2 ISHLT 2005 J Heart Lung Transplant 2005;24:

62 ADULT HEART TRANSPLANTS (1/1995-6/2003) 1-Year Predicted Survival – Hypothetical Patient 3 ISHLT 2005 J Heart Lung Transplant 2005;24:

63 ADULT HEART TRANSPLANTS (1/1995-6/2003) 1-Year Predicted Survival – Hypothetical Patient 4 ISHLT 2005 J Heart Lung Transplant 2005;24:

64 ADULT HEART TRANSPLANTS (1996-6/1999) Risk Factors for 5 Year Mortality (N=11,794) 2005 ISHLT J Heart Lung Transplant 2005;24:

65 ADULT HEART TRANSPLANTS (1996-6/1999) Risk Factors for 5 Year Mortality (N=11,794) 2005 ISHLT J Heart Lung Transplant 2005;24:

66 ADULT HEART TRANSPLANTS (1996-6/1999) Borderline Significant Risk Factors for 5 Year Mortality (N=11,794) 2005 ISHLT J Heart Lung Transplant 2005;24:

67 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality 2005 ISHLT J Heart Lung Transplant 2005;24:

68 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

69 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

70 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Pre-Transplant Recipient Weight 2005 ISHLT J Heart Lung Transplant 2005;24:

71 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

72 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Donor Weight/Recipient Weight Ratio 2005 ISHLT J Heart Lung Transplant 2005;24:

73 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Center Volume 2005 ISHLT J Heart Lung Transplant 2005;24:

74 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Ischemia Time 2005 ISHLT J Heart Lung Transplant 2005;24:

75 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Pre-Transplant Creatinine 2005 ISHLT J Heart Lung Transplant 2005;24:

76 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Pre-Transplant Bilirubin 2005 ISHLT J Heart Lung Transplant 2005;24:

77 ADULT HEART TRANSPLANTS (1/1996-6/1999) Factors Not Significant for 5 Year Mortality Recipient Factors: VAD, gender, pulmonary vascular resistance, PA systolic, PA diastolic, thoracotomy, sternotomy, pregnancy, history of malignancy, pneumothorax, pulmonary embolism symptomatic cerebrovascular disease/ cerebrovascular event Donor Factors: Gender, history of diabetes, history of cancer, clinical infection, cause of death, history of hypertension Transplant Factors: Donor/recipient BMI ratio, ABO identical/compatible 2005 ISHLT J Heart Lung Transplant 2005;24:

78 ADULT HEART TRANSPLANTS (1/1995-6/1999) 5-Year Predicted Survival – Hypothetical Patient 1 ISHLT 2005 J Heart Lung Transplant 2005;24:

79 ADULT HEART TRANSPLANTS (1/1995-6/1999) 5-Year Predicted Survival – Hypothetical Patient 2 ISHLT 2005 J Heart Lung Transplant 2005;24:

80 ADULT HEART TRANSPLANTS (1/1995-6/1999) 5-Year Predicted Survival – Hypothetical Patient 3 ISHLT 2005 J Heart Lung Transplant 2005;24:

81 ADULT HEART TRANSPLANTS (1/1995-6/1999) 5-Year Predicted Survival – Hypothetical Patient 4 ISHLT 2005 J Heart Lung Transplant 2005;24:

82 ADULT HEART TRANSPLANTS (1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year (N=9,120) 2005 ISHLT J Heart Lung Transplant 2005;24:

83 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year 2005 ISHLT J Heart Lung Transplant 2005;24:

84 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

85 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

86 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Pre-Transplant Recipient Weight 2005 ISHLT J Heart Lung Transplant 2005;24:

87 ADULT HEART TRANSPLANTS (1/1996-6/1999) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

88 ADULT HEART TRANSPLANTS (1/1996-6/1999) Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year Recipient Factors: Diagnosis, gender, ventilator, VAD, in hospital, IV inotropes, dialysis, infection prior to transplant, transfusions, PRA, balloon, pulmonary embolism, PA pressures, PCW, pulmonary vascular resistance, cardiac output, history of malignancy, height, sternotomy, bilirubin, pregnancy 2005 ISHLT J Heart Lung Transplant 2005;24:

89 ADULT HEART TRANSPLANTS (1/1996-6/1999) Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year Donor Factors: Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes Transplant Factors: Donor/recipient BMI ratio, donor/recipient weight ratio, CMV mismatch, center volume, ischemia time, ABO compatible/identical Post-transplant Factors: Dialysis, prolonged graft dysfunction, permanent pacemaker 2005 ISHLT J Heart Lung Transplant 2005;24:

90 ADULT HEART TRANSPLANTS (1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years (N=10,982) 2005 ISHLT J Heart Lung Transplant 2005;24:

91 ADULT HEART TRANSPLANTS (1990-6/1993) Borderline Significant Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years (N=10,982) 2005 ISHLT J Heart Lung Transplant 2005;24:

92 ADULT HEART TRANSPLANTS (1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years 2005 ISHLT J Heart Lung Transplant 2005;24:

93 ADULT HEART TRANSPLANTS (1/1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

94 ADULT HEART TRANSPLANTS (1/1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

95 ADULT HEART TRANSPLANTS (1/1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

96 ADULT HEART TRANSPLANTS (1/1990-6/1993) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor Weight 2005 ISHLT J Heart Lung Transplant 2005;24:

97 ADULT HEART TRANSPLANTS (1/1990-6/1993) Conditional 10-Year Predicted Survival – Hypothetical Patient 1 ISHLT 2005 J Heart Lung Transplant 2005;24:

98 ADULT HEART TRANSPLANTS (1/1990-6/1993) Conditional 10-Year Predicted Survival – Hypothetical Patient 2 ISHLT 2005 J Heart Lung Transplant 2005;24:

99 ADULT HEART TRANSPLANTS (1/1990-6/1993) Conditional 10-Year Predicted Survival – Hypothetical Patient 3 ISHLT 2005 J Heart Lung Transplant 2005;24:

100 ADULT HEART TRANSPLANTS (1/1990-6/1993) Conditional 10-Year Predicted Survival – Hypothetical Patient 4 ISHLT 2005 J Heart Lung Transplant 2005;24:

101 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years (N=6,730) 2005 ISHLT J Heart Lung Transplant 2005;24:

102 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years 2005 ISHLT J Heart Lung Transplant 2005;24:

103 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

104 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

105 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

106 ADULT HEART TRANSPLANTS (1996-6/2001) Risk Factors for Developing Coronary Artery Vasculopathy within 3 Years Center Volume 2005 ISHLT J Heart Lung Transplant 2005;24:

107 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year (N=1,461) 2005 ISHLT J Heart Lung Transplant 2005;24:

108 ADULT HEART TRANSPLANTS (1996-6/1997) Borderline Significant Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year (N=1,461) 2005 ISHLT J Heart Lung Transplant 2005;24:

109 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year 2005 ISHLT J Heart Lung Transplant 2005;24:

110 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Recipient Age 2005 ISHLT J Heart Lung Transplant 2005;24:

111 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Donor Age 2005 ISHLT J Heart Lung Transplant 2005;24:

112 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Pre-Transplant Recipient BMI 2005 ISHLT J Heart Lung Transplant 2005;24:

113 ADULT HEART TRANSPLANTS (1996-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Center Volume 2005 ISHLT J Heart Lung Transplant 2005;24:


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