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2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. LUNG TRANSPLANTATION Pediatric Recipients.

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Presentation on theme: "2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. LUNG TRANSPLANTATION Pediatric Recipients."— Presentation transcript:

1 2002 ISHLT J Heart Lung Transplant 2002; 21: LUNG TRANSPLANTATION Pediatric Recipients

2 2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS

3 2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS ( )

4 2002 ISHLT J Heart Lung Transplant 2002; 21: AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant Number of Transplants * Numbers may be low due to delayed reporting.

5 2002 ISHLT J Heart Lung Transplant 2002; 21: NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS * Numbers may be low due to delayed reporting.

6 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION: Indications ( ) DIAGNOSISAGE: < 1 YearAGE: 1-10 Years Cystic Fibrosis5534.2% PPH716.7%2414.9% Congenital Heart Disease1433.3%1710.6% IPF127.5% Pulmonary Vascular Disease614.3%63.7% Re-TX: Non-OB37.1%85.0% Re-TX: OB95.6% OB (Non-ReTX)63.7% Bronchiectasis21.2% COPD/Emphysema21.2% Other1126.2%1710.6%

7 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Indications by Age ( ) Age <1 Year Age 1-10 Years

8 2002 ISHLT J Heart Lung Transplant 2002; 21: DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: Years

9 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type ( ) P = 0.006

10 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Age Group ( ) <1 Year: ½-life = 3.5 Years 1-10 Years: ½-life = 3.5 Years Years: ½-life = 3.2 Years

11 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Conditional Actuarial Survival by Age Group ( ) <1 Year: ½-life = 7.1 Years 1-10 Years: ½-life = 5.9 Years Years: ½-life = 5.4 Years

12 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Era ( ) Survival (%)

13 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH ( ) P = 0.002

14 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Functional Status (April 1994-December 2001)

15 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant (April December 2001)

16 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

17 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

18 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

19 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December Year Follow-up (N = 76)5 Year Follow-up (N = 39)

20 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up Report For follow-ups between October 1999 and December 2001

21 2002 ISHLT J Heart Lung Transplant 2002; 21: POST-LUNG TRANSPLANT MORBIDITY For Pediatric Recipients (April 1994-December 2000)

22 2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients (April 1994-December 2000)

23 2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Renal Dysfunction* For Pediatric Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

24 2002 ISHLT J Heart Lung Transplant 2002; 21: MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy288 (93.5%)45 (91.8%) Malignancy (all types combined)20 (6.5%)4 (8.2%) Malignancy Type Lymph184 Other2

25 2002 ISHLT J Heart Lung Transplant 2002; 21: Freedom from Malignancy For Pediatric Lung Recipients (April 1994-December 2000)

26 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year ( ) Survival (%) P= 0.01

27 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS Relationship of Diabetes and Cystic Fibrosis Transplants: April 1994 – December 2000 Diagnosis Report of Diabetes Developing Between Transplant and 1st Year* Report of Diabetes Developing Between Transplant and 3rd Year** NoYesNoYes Cystic Fibrosis % % % % Other Diagnosis % 4 2.8% % 3 5.4% *p < **p <

28 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG RECIPIENTS: Time Of Death ( )

29 2002 ISHLT J Heart Lung Transplant 2002; 21: PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause of Death ( ) Timing of Death


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