1. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. HEART-LUNG TRANSPLANTATION Overall

2. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR

3. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AVERAGE CENTER VOLUME Heart-Lung Transplants: January 1, 1998 - June 30, 2002

4. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. HEART-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (Transplants: January 1982 - June 2001) N=2,889 Half-life = 2.7 years Conditional Half-life = 8.1 years Survival (%)

5. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. HEART-LUNG TRANSPLANTATION Adult Recipients

6. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (1/1982-6/2002) Other includes cancer, LAM, OB, sarcoidosis, bronchiectasis

7. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (Transplants: January 1982 - June 2002) Diagnosis N (%) Congenital Heart Disease 705 ( 32.2% ) PPH 526 ( 24.0% ) CF 341 ( 15.6% ) Acquired Heart Disease 91 ( 4.2% ) COPD/Emphysema 88 ( 4.0% ) IPF 60 ( 2.7% ) Alpha-1 58 ( 2.6% ) Re-TX: Non-OB 31 ( 1.4% ) Sarcoidosis 26 ( 1.2% ) Re-TX: OB 23 ( 1.1% ) Bronchiectasis 14 ( 0.6% ) OB (not Re-TX) 8 ( 0.4% ) Other 219 ( 10.0% ) TOTAL 2,190 (100.0%)

8. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA 1982-19901991-19951/1996-6/2002 Other includes OB (non-ReTX), Bronchiectasis, Sarcoidosis

9. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (Transplants: January 1990 – June 2001)

10. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (Transplants: January 1990 – June 2001)

11. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Functional Status (Follow-ups: April 1994 – June 2002)

12. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Employment Status (Follow-ups: April 1994 – June 2002)

13. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS: Rehospitalization Post-transplant (Follow-ups: April 1994 - June 2002)

14. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression For follow-ups between January 2000 through June 2002

15. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression (Follow-ups: January 2000 - June 2002)

16. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

17. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

18. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

19. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994-June 2002)

20. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994-June 2002)

21. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from CAV For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2002)

22. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from Bronchiolitis Obliterans For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2002)

23. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from Severe Renal Dysfunction* For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2002) *Severe renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

24. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTS Cumulative Prevalence in Survivors (Follow-ups: April 1994-June 2002) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy 228 (91.2%) 58 (89.2%) Malignancy (all types combined) 22 (8.8%) 7 (10.8%) Malignancy Type Skin22 Lymph152 Other11 Type Not Reported42

25. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from Malignancy For Adult Heart-Lung Recipients (Follow-ups: April 1994- June 2002)

26. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January 1992 - June 2002) CAUSE OF DEATH 0-30 Days (N = 164) 31 Days - 1 Year (N = 107) >1 Year - 3 Years (N = 95) >3 Years - 5 Years (N = 53) >5 Years (N = 74) BRONCHIOLITIS4 (3.7%)24 (25.3%)21 (39.6%)15 (20.3%) ACUTE REJECTION2 (1.2%)3 (2.8%)1 (1.1%)1 (1.9%) LYMPHOMA3 (2.8%)4 (4.2%)3 (5.7%)1 (1.4%) MALIGNANCY, OTHER1 (0.9%)6 (6.3%)2 (3.8%)5 (6.8%) CMV1 (0.9%)1 (1.9%) INFECTION, NON-CMV34 (20.7%)47 (43.9%)31 (32.6%)3 (5.7%)10 (13.5%) GRAFT FAILURE71 (43.3%)27 (25.2%)19 (20.0%)9 (17.0%)22 (29.7%) CARDIOVASCULAR2 (1.2%)3 (3.2%)5 (9.4%)3 (4.1%) TECHNICAL29 (17.7%)1 (0.9%)1 (1.1%) OTHER26 (15.9%)20 (18.7%)6 (6.3%)8 (15.1%)18 (24.3%)

27. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. HEART-LUNG TRANSPLANTATION Pediatric Recipients

28. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS (Transplants: January 1982 - June 2002)

29. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART- LUNG RECIPIENTS (Transplants: January 1982 - June 2002)

30. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS By Year of Transplant Number of Transplants

31. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS

32. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN PEDIATRIC HEART –LUNG TRANSPLANT RECIPIENTS (Age: 11-17 Years) Other includes Alpha-1, Bronchiectasis, IPF and OB (non-ReTX)

33. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (Transplants: January 1990 – June 2001)

34. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (Transplants: January 1990 – June 2001)

35. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival (Transplants: January 1982 - June 2002) 1-10 years vs. 11-17 years p = 0.9

36. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival by Era (Transplants: January 1982 - June 2001) Survival (%)

37. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January 1992 - June 2002) CAUSE OF DEATH0-30 Days (N = 20) 31 Days - 1 Year (N = 24) >1 Year - 3 Years (N = 25) >3 Years - 5 Years (N = 16) >5 Years (N = 16) BRONCHIOLITIS1 (4.2%)13 (52.0%)8 (50.0%)4 (25.0%) ACUTE REJECTION1 (4.2%) INFECTION, OTHER5 (25.0%)9 (37.5%)5 (20.0%)1 (6.3%)5 (31.3%) GRAFT FAILURE10 (50.0%)5 (20.8%)5 (20.0%)5 (31.3%) TECHNICAL3 (15.0%)1 (4.2%) OTHER2 (10.0%)7 (29.2%)2 (8.0%)2 (12.5%)