1. 2001 THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT

2. 2001 ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible.

3. 2001 REGISTRY DATABASE

4. 2001 REGISTRY DATABASE

5. 2001 HEART TRANSPLANTATION * Numbers may be low due to incomplete reporting. Number of Transplants * * 12% 9% 6% 3% % donors 50-55 % donors 50+ Percent of Donors by Age

6. 2001 AGE DISTRIBUTION OF HEART RECIPIENTS (1982-2000) % of Trnsplants % of Transplants

7. 2001 ADULT HEART TRANSPLANTATION INDICATIONS

8. 2001 AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS Number of Transplants 119 42 75 111 128 194 255 326 365 363 386 362 374 346 375 352 332 347

9. 2001 PEDIATRIC HEART TRANSPLANTATION INDICATIONS BY AGE (1982-1999) < 1 Year1-10 Years11-17 Years

10. 2001 HEART TRANSPLANTATION ACTUARIAL SURVIVAL (1982-2000) N=52,195 Half-life =9.1 years Conditional Half-life = 11.6 years

11. 2001 ADULT HEART TRANSPLANTATION ACTUARIAL SURVIVAL All comparisons with 1980-1987 are significant at p < 0.0001 Survival (%)

12. 2001 ADULT HEART RE-TRANSPLANTATION (1982-1999) 1 Year Patient Survival (%)

13. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

14. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943 * * Latest period in cohort

15. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

16. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

17. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

18. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

19. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

20. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

21. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

22. 2001 PEDIATRIC HEART TRANSPLANTATION ACTUARIAL SURVIVAL (1982-2000) All comparisons with <1 year significant at p < 0.0001

23. 2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=3,760 * Earliest period in cohort *

24. 2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=3,760

25. 2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465 * Latest year in cohort *

26. 2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465

27. 2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465

28. 2001 FUNCTIONAL STATUS Heart (April 1994-Dec. 2000)

29. 2001 EMPLOYMENT STATUS Heart (US Data: April 1994-Dec. 2000)

30. 2001 REHOSPITALIZATION POST HEART TRANSPLANTATION (April 1994 - Dec. 2000)

31. 2001 HEART TRANSPLANT MAINTENANCE IMMUNOSUPPRESSION % of Patients

32. 2001 HEART TRANSPLANTATION Donor age versus Ejection Fraction yr 1 to yr 2

33. 2001 POST-HEART TRANSPLANT MORBIDITY (April 1994-December 2000)

34. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

35. 2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

36. 2001 MALIGNANCY POST-HEART TRANSPLANTATION (April 1994-December 2000) 1-Year Followup 5-Year Followup

37. 2001 HEART TRANSPLANTS: CAUSE OF DEATH (1982-2000) Timing of Death Cause of Death (%)

38. 2001 HEART-LUNG TRANSPLANTATION

39. 2001 ADULT HEART-LUNG TRANSPLANTATION INDICATIONS (1982-2000)

40. 2001 HEART-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (1982-2000) N=2,550 Half-life = 2.8 years Conditional Half-life = 8.2 years Survival (%)

41. 2001 LUNG TRANSPLANTATION Mean Donor Age 4 7 38 74 184 404 675 887 1062 1176 1331 1284 13861385 1325 1412

42. 2001 AGE DISTRIBUTION OF LUNG TRANSPLANTATION

43. 2001 ADULT LUNG TRANSPLANTATION INDICATIONS (1983-2000) Single Lung Bilateral/Double Lung

44. 2001 PEDIATRIC LUNG TRANSPLANTATION AGE DISTRIBUTION (1986-2000) Number of Transplants 1 34 6 19 47 50 45 41 80 68 8586 6465

45. 2001 PEDIATRIC LUNG TRANSPLANTATION INDICATIONS (1986-2000)

46. 2001 LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (1983-2000) Double lung: 1/2-life = 4.5 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.6 Years; Conditional 1/2-life = 5.7 Years All lungs: 1/2-life = 3.8 Years; Conditional 1/2-life = 6.3 Years

47. 2001 ADULT LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (1988-2000) Comparison of 1988-1992 vs. 1997-2000 was significant at p = 0.002

48. 2001 PEDIATRIC LUNG/HRT-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (1984-2000)

49. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653 * Earliest period in cohort *

50. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

51. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

52. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

53. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

54. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050 * Earliest period in cohort *

55. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

56. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

57. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

58. 2001 FUNCTIONAL STATUS Lung (April 1994-December 2000)

59. 2001 EMPLOYMENT STATUS Lung (US: April 1994-December 2000)

60. 2001 REHOSPITALIZATION POST LUNG TRANSPLANTATION (April 1994 - December 2000)

61. 2001 POST-LUNG TRANSPLANT MORBIDITY (April 1994-December 2000)

62. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756 ** Latest year in cohort * Earliest year in cohort * **

63. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756

64. 2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756

65. 2001 MALIGNANCY POST-LUNG TRANSPLANTATION (April 1994-December 2000) 1-Year Followup 5-Year Followup

66. 2001 LUNG TRANSPLANTS: CAUSE OF DEATH (1982-2000) Timing of Death Cause of Death (%)