Presentation on theme: "FamiliesUSA The Neglected Tropical Diseases Peter Hotez MD PhD FAAP The George Washington University Sabin Vaccine Institute."— Presentation transcript:
FamiliesUSA The Neglected Tropical Diseases Peter Hotez MD PhD FAAP The George Washington University Sabin Vaccine Institute
The Millennium Development Goals (MDGs) 1. Eradicate extreme poverty and hunger. 2. Achieve universal primary education. 3. Promote gender equality and empower women. 4. Reduce child mortality. 5. Improve maternal health. 6. Combat HIV/AIDS, malaria and other diseases. 7. Ensure environmental sustainability. 8. Develop a global partnership for development. The 2000 Millennium Declaration
The Neglected Tropical Diseases Ancient Afflictions of Stigma and Poverty Core Group of 13 Protozoan Infections –African Trypanosomiasis –Chagas Disease –Leishmaniasis Bacterial Infections –Buruli Ulcer –Leprosy –Trachoma Helminth Infections –Ascariasis –Hookworm Infection –Trichuriasis –Schistosomiasis –Lymphatic Filariasis –Onchocerciasis –Dracunculiasis
DiseaseNumber of CasesPopulation at-risk Ascariasis807 million4.2 billion Trichuriasis604 million3.2 billion Hookworm576 million3.2 billion Schistosomiasis200 million0.6 billion Lymphatic Filariasis120 million1.0 billion Trachoma84 million0.5 billion Onchocerciasis18-37 million0.1 billion Leishmaniasis12 million0.4 billion Chagas Disease8-9 million0.025 billion Leprosy0.4 millionND Trypanosomiasis0.3 millionND Dracunculiasis0.01 millionND The Most Common Infections of Poor People
Neglected Tropical Diseases COMMON FEATURES The Most Prevalent Infections of Poor People –Up to half of the 2.7 billion people who live on less than $2 per day –Rural areas (slums and poor urban areas) of low-income countries Non-Emerging Ancient Conditions Indigenous Populations Chronic Conditions Disabling Conditions –Growth Delays –Blindness –Disfigurement –Stigma Poverty Promoting Conditions –Child development and education –Pregnancy outcome –Productive capacity
Buruli Ulcer Onchocerciasis Leishmaniasis
Its quite a problem for me when I have to stand at work for long periods.
I am a fisherman. I cant work continuously. I am ill every other week with renewed pain.
My parents brought me two suitors but neither decided to marry me.
Lymphatic Filariasis in Sri Lanka
Ranking of Communicable Diseases By DALYs Disease ConditionDisease Burden HIV-AIDS84.5 million Neglected Tropical Diseases56.6 million Malaria46.5 million Tuberculosis34.7 million Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, Sachs JD PLoS Medicine 2006; 3: e102
Version 2.0: Integrating Neglected Tropical Disease Control
Low Cost of Interventions <$0.50 for packaged intervention – delivery costs for donated drugs
Global Network for Neglected Tropical Diseases Schistosomiasis Control Initiative International Trachoma Initiative Helen Keller International Liverpool School - GAELF Human Hookworm Vaccine Initiative Earth Institute at Columbia Univ. Task Force for Child Survival –Mectizan Donation Program –Albendazole Donation Program –Mebendazole Donation Program
8 / 56 Countries Geneva Global Burundi Rwanda Exxon Mobil Equatorial Guinea USAID Burkina Faso Ghana Mali Niger Uganda New NTD Control Projects The Global Network for Neglected Tropical Disease Control
The Buzz on NTDs The world is now paying attention to these [neglected] diseases and making progress in unprecedented ways, with ambitious goals, excellent interventions, and growing evidence of multiple benefits for health. The attention to long- neglected diseases is a positive sign that health is a responsibility shared by the international community. -Dr. Margaret Chan, Director-General of the World Health Organization Comprehensive, Africa-wide control of malaria and NTDs together would probably cost no more than $3 billion a year, or just two days of Pentagon spending. If each of the billion people in the rich world devoted the equivalent of one $3 coffee a year to the cause, several million children every year would be spared of death and debility, and world would be spared the grave risks when disease and despair run unchecked. A new Global Network for Neglected Tropical Disease Control is helping make this opportunity a reality. - Jeffrey Sachs, Director of the Earth Institute, Scientific American January 2007 It quickly became clear that this story is not just about the staggering numbers of the worlds citizens overwhelmed by HIV, AIDS, TB, and malaria. And its not just the story about one billion people who are afflicted with disabling, oftentimes stigmatizing, neglected tropical diseases, such as human hookworm infection and elephantiasis… its all about the faces of dying children and sick mothers who haunt those who have seen them...What struck me, and what I think struck us all…that these challenges are all interconnected. - Clinton Global Initiative, Closing Remarks
VERSION 3.0: NEW TOOLS FOR DISEASE CONTROL Low efficacy of Mebendazole Re-infection within 4-12 mos Diminishing efficacy Hookworm Re-Infection Product Development Partnership Sabin Vaccine Institute George Washington University FIOCRUZ Instituto Butantan London School Hyg. Trop. Med. Queensland Inst. Med. Res