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Terry J. Opgenorth Abbott Laboratories Academic-Industry Collaboration Terry J. Opgenorth Abbott Laboratories The Development of Endothelin Receptor Antagonists.

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Presentation on theme: "Terry J. Opgenorth Abbott Laboratories Academic-Industry Collaboration Terry J. Opgenorth Abbott Laboratories The Development of Endothelin Receptor Antagonists."— Presentation transcript:

1 Terry J. Opgenorth Abbott Laboratories Academic-Industry Collaboration Terry J. Opgenorth Abbott Laboratories The Development of Endothelin Receptor Antagonists for the Treatment of Prostate Cancer Lessons for Career Development

2 Career Preparation for Industry search Out presentations/abstracts from biotech and pharma companies read pharmacology journals correspond with authors – request compounds –Proposal – mutual benefit => collaborate

3 1996: Atrasentan publication 54 publications (18 Abbott-only authors) Nelson Lab 15 pubs/6 with Abbott Bagnatto Lab 15 pubs/3 with Abbott 1995: Bagnatto Lab ET mitogenic/cancer 1995 (Dec): Candidate Declared 1995: J. Nelson Prostate Cancer Hypothesis : Lepor Lab 3 pubs - Prostate To 1995: 30 publications (24 Abbott-only authors) 1990: 2 Abbott ET publications 1988: Discovery of Endothelin Abbott ET Project Begins ACADEMIA INDUSTRY

4 Wall Street Journal – May 14, 2001 An Abbott VP happened to be in the audience and soon got Dr. Nelson together with Abbott researchers working on the endothelin program… …a compound in search of disease….We were planning to bring if forward as a cardiovascular agent

5 J. Clin. Oncol. 21: , 2003 Abbott & Hopkins researchers are primary authors

6 Nat. Rev. Cancer 3: , 2003 Abbott Rome Laval U. U. Pitt.

7 Physiologists in Pharma and Biotech Research Physiologist Molecular Cell Organ Animal Pharmacologist Molecular Cell Organ Animal Integrative Systems Drug Discovery Drug DRC

8 Career Preparation for Industry search Out presentations/abstracts from biotech and pharma companies read pharmacology journals correspond with authors – request compounds –Proposal – mutual benefit => collaborate


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