2. ANAPHYLACTIC REACTION

3. ANAPHYLACTIC SHOCK DEFINED: Acute systemic hypersensitivity reaction that occurs within seconds to minutes after exposure to a variety of foreign substances SUCH AS: medications (penicillin, IVP dye), stinging insects CAUSED BY: an antigen antibody response

4. Clinical manifestations Wide range of clinical manifestations

5. SKIN MANIFESTATIONS flushing, sense of warmth, diffuse erythema, generalized itching, uriticaria (hives), facial angioedema leading to respiratory edema

6. RESPIRATORY SIGNS nasal congestion, itching, sneezing, coughing, bronchospasm, edema of the larynx, tightness of the chest, wheezing, dyspnea, cyanosis

7. CARDIOVASCULAR Tachycardia Bradycardia PERIPHERAL VASCULAR COLLAPSE: pallor, imperceptible pulse, decreasing BP, circulatory failure leading to coma, death

8. PREVENTION Determine what patient allergic too through sensitivity testing via allergist Wear medic alert bracelet Carry epi-pen, check expiration date

9. GASTROINTESTINAL Nausea, vomiting, colicky abdominal pains or diarrhea

10. NURSING DIAGNOSIS Decreased cardiac output Impaired gas exchange Risk for fluid volume deficit Anxiety

11. EMERGENCY MANAGEMENT Establish an airway while another person gives epinephrine; administer oxygen Epinephrine SQ or IV provides rapid relief of hypersensitivity reaction and may be repeated EPINEPHRINE: given to restore vascular tone and raise arterial BP; vasoconstricts DOSE: 1:1000 sol (0.3ml SQ q 5-15 min) DOSE: 1:10,000 sol (0.5-1mg IV q 5 min)

12. EMERGENCY TX CONTINUED Remove the antigen (blood, penicillin IV, or other antibiotic) Benadryl IV push – antihistamine effect, reverses histamine effects (vaso-dilation and broncho- constriction) Solu-Medrol IVPB as an anti- inflammatory Pepcid IVPB to prevent gastric irritation from steroids

13. EMERGENCY TX CONTINUED Check if patient is on beta- adrenergic blocking drugs such as Inderal; These drugs decrease the effectiveness of the epinephrine Patient may have a recurrence of symptoms 6-8 hours after initial anaphylactic reaction