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A presentation by Prof. David A. Rivkin, PhD

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Presentation on theme: "A presentation by Prof. David A. Rivkin, PhD"— Presentation transcript:

1 “Its all about the timing… Echo cardiogram enhancement through ECG/EKG triggering”
A presentation by Prof. David A. Rivkin, PhD President & Chief Scientist, GCPI Adjunct Professor, Drexel University IEEE Senior Member, EMBS Distinguished Lecturer Chairman, IEEE SCV Instrumentation and Measurement Society Chairman, IEEE Instrumentation and Measurement Society Technical Committee 34 “Nanotechnology In Instrumentation and Measurement” IEEE Nanotech Council Executive Member AdvaMed Medical Device Industry Council Advisor ISO TC-229 “Nanotechnology Standards” IEEE Liaison Chairman, STI Emerging Technologies SIG Fellow, Society for Industrial & Applied Mathematics

2 Timing of the Presentation
The Problem – Blurry Pictures… Previous Solutions – Big Computers… New Solution – Embedded Monitor/Trigger Unified Solution – Best Timely Results Overview of Design – How it works Overview of Management – Why its on time Conclusion – Its about time

3 The Problem – Blurry Pictures
X-Ray Echo Cardiogram CT 3D Ultrasound PET Electrical Impedance Tomography (IET)

4 The Problem – Blurry Pictures
Issue Patient Moves Breathing Heart Beating Possible Solution Restrain Patient Hold Breath Nothing…till now

5 The Problem – Echo Cardiograms
Measurements of cardiac muscle and arteries need to be taken Heart Beating Dimensions Change over Heart Rhythm Cycle

6 The Problem – 3D Imaging 3D Ultrasound 3D Echocardiogram
X-Ray Computed Tomography MRI

7 The Problem – Invasion When Imaging Is Inconclusive, Invasive measures must be taken E.g. Open Heart Surgery Always a risk of complications

8 Previous Solutions – Big Computers…
NASA Bartron Medical Imaging (defunct) GCPI Redundant Shadowing Advanced CT algorithms Cluster Computing & Supercomputers

9 Previous Solutions – Big Computers…
NASA Bartron Medical Imaging GCPI Redundant Shadowing – Determine Regions of Motion Causing Error Advanced CT algorithms Compensate for Motion with estimation and redundant data

10 New Solution – Embedded Monitor/Trigger
Electro Cardiogram (ECG/EKG) Use ECG Data to Trigger Imager Signal Processing to Determine Trigger Point

11 New Solution – Embedded Monitor/Trigger
Electro Cardiogram (ECG/EKG) Data: Well known Simple to collect Up to 12 Point Data Collection

12 New Solution – Embedded Monitor/Trigger
Peaks can act as simple triggers E.g. Trigger on Ventricular Contraction

13 New Solution – Embedded Monitor/Trigger
ECG Signals Indicate more complex activities of the heart than just Ventricular Contraction Any Phase of the Cardiac Rhythm can be determined

14 New Solution – Embedded Monitor/Trigger
ECG with Signal Processing can Trigger at any point, on any peak or with delays Some imagers (such as ultrasound) have inherent delay allowing for triggering to be after the image is already collected

15 New Solution – Embedded Monitor/Trigger
ECG based software control of triggering Advanced algorithms can be used to trigger only upon abnormalities in ECG data

16 New Solution – Embedded Monitor/Trigger
Proper triggering can enhance location of abnormalities in heart dimensions or function E.g. Abnormal Blood Flow indicating hole in heart wall otherwise not detected

17 Unified Solution – Best Timely Results
Combining Advanced Triggering with Advanced CT Algorithms results in the best images

18 Overview of Design – How it works
Standard 3M RedDot adhesive electrodes Standard connectors and cabling

19 Overview of Design – How it works
Virtex-4 LX25 FPGA 24,192 Logic Cells 128 MB RAM 64 MB Flash ROM JTAG Hardware Debugging 48 Billion Multiply and Accumulates / Second Mechanical Specification Temperature Range: -40° C to +85° C Developed on Standard Virtex4 Prototype Board

20 Overview of Design – How it works
Virtex4 Versions Considered DX - PowerPC Core/DualCore SX - XtremeDSP Slice Overkill for the application Would have taken longer to develop

21 Overview of Design – How it works
Developed Entirely in SystemC Prototyped on Dual Processor AMD64 desktop SystemC to VHDL by SystemCrafter SC Xilinx IDE WebPack GBit Ethernet, USB or Serial Update of EEPROM

22 Overview of Design – How it works
Isolation/Instrumentation Amplifiers and Isolation Power Supply TTL, CMOS, RS-232 and USB Trigger Lines Provided for different manufacturers interfacing needs Miniature Stainless Steel Enclosure EMI Shielded Cabling

23 Overview of Management – Why its on time…and under budget
5 Months from conception to First Articles generated by CEM, scheduled for 6 months Under Budget by 4% Entering Clinical Trials currently Compliant with ISO13485:2005 and 21CFR820 “Avoid Verbal Orders, Say It In Writing”

24 Overview of Management – Why its on time…and under budget
Program Management Under: GPES Stochastic Methods Quality Scientific & Engineering Collaboration NASA Distributed Engineering Team at GCPI

25 Overview of Management – Why its on time…and under budget
GPES – Global Performance Evaluation System Real-Time Program & Project Status Developed by NASA at Johnson Space Center Open Source ASP on MS SQLServer

26 Overview of Management – Why its on time…and under budget
GPES Source Code Modified to Use Stochastic Methods (o) = Most optimistic duration - everything will go according to plan with a minimal amount of difficulties. (p) = Most pessimistic duration - everything will not go according to plan and maximum potential difficulties will develop. (m) = Most likely duration - will most often occur should this effort be repeated over and over again = the sum of all critical path expected times. = the sum of all critical path variances. = the number of standard deviations of a normal distribution (the standard normal deviate) Values for Z can be taken from “Project Management, A Managerial Approach,” Jack R. Meredith and Samuel J. Mantel, Jr., John Wiley & Sons, NY, 1995

27 Overview of Management – Why its on time…and under budget
Quality Scientific & Engineering Collaboration NASA – 5 Researchers AMES Research Center Johnson Space Center GCPI – 18 Engineers (EEs, SEs, ME) 3 Offices: San Jose, Baltimore, London Telecommute Design Staff Medical Imaging Partners GE, Philips Contract Manufacturing Partners Flextronics, Benchmark

28 Conclusion – Its about time
New and exciting technologies are changing the way products are developed. SystemC offers new ways to design, prototype and develop unified Software/Hardware products using non-traditional computing methods

29 Conclusion – Its about time!
Any Questions? Thank you for your patience! By Prof. David A. Rivkin, PhD


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