1. Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Measurement Science and Systems Engineering at the Oak Ridge National Laboratory Energy and Engineering Science Directorate Kenneth W. Tobin, Ph.D. Director Corporate Research Fellow Measurement Science and Systems Engineering Division 1 st Annual ORNL Biomedical Science and Engineering Conference 18-19 March 2009

2. 2 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Measurement Science and Systems Engineering (MSSE)  MSSE performs applied R&D in measurement science associated with …  We perform and support research in  Energy research (DOE, NRC, DOD, Industry, …)  National security (NNSA, DHS, DOD, DARPA, …)  Biomedical engineering (OBER, NIH, DARPA, DOD, TATRC …)  Basic Science (DOE, DARPA, …)  U.S. Competitiveness (U.S. Industry, WFO, …) Electronics CommunicationsSensors Signals / Patterns Robotics Systems

3. 3 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Measurement Science  We research and produce highly accurate and precise measurement technologies for complex, harsh, and high data-volume environments PHENIX detector subsystem: 300,000 readout channels, 40  s refresh rate, timing resolution <25ps MEMS/NEMS devices to measure small displacements (0.1pm/Hz -1/2 ), mass (10fg), and chemical concentration (ppt) Holographic microscopy: 1nm precision, metrology and motion (3D trajectory) Plasma temperature for Advanced Toroidal Facility (ATF): 0.1-20MK VACNF arrays for measuring neuro-electrical activity (neuronal interface): can resolve neurotransmitters at sub- attomolar concentrations

4. 4 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Systems Engineering  We have significant strengths in our ability to produce unique, complex, and robust integrated systems that meet the operating requirements of diverse environments and applications Army rad- hardened chemical and biological mass spectrometer Navy underwater acoustics measurement facility Electronics for high-energy physics at RHIC Human amplification platform for Navy High-resolution multi-modal pre-clinical scanner for industry Microscopy system semiconductor industry

5. 5 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Biomedical Engineering  Our biomedical engineering research enables measurements and analysis that impact human health in a number of important areas http://www.uchsc.edu/sm/chs/browse/browse_m.html Image-based diagnosis and screening Preclinical anatomic and functional imaging Nano-structured substrates for tissue scaffolding Intraoperative surgical imaging Quantitative phase imaging of biological materials NIR imaging and 3D tissue modeling Transplant tissue monitoring systems

6. 6 Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov Kenneth W. Tobin, Director, Measurement Science and Systems Engineering Division, Ph: (865) 574-0355, E-mail: tobinkwjr@ornl.gov  MSSE was formed in 2008 to build upon sixty years of scientific and engineering research at ORNL  Today we perform R&D in electronics, signals, patterns, communications, and informatics  Applying our skills and experience to the field of biomedical science has become an important research area for the applied science organizations at ORNL … Conclusion DOE OBER