Presentation on theme: "INTRA-NASAL DRUG DELIVERY SYSTEM"— Presentation transcript:
1INTRA-NASAL DRUG DELIVERY SYSTEM A SEMINAR ONINTRA-NASAL DRUG DELIVERY SYSTEMBY:NALEEN RAJ BHANDARIB-PHARM (2/4)MAHESHWARA INSTITUTE OF PHARMACY
2CONTENTS INTRODUCTION ADVANTAGES FUNDAMENTAL FACTORS MECHANISMS AND PATHWAYSDELIVERY SYSTEMSENHANCEMENT IN ABSORPTIONAPPLICATIONSEXAMPLESCONCLUSIONSREFERENCES
3INTRODUCTIONIn ancient times the Indian Ayurvedic system of medicines used nasal route for administration of drug and the process is called as “Nasya”It has been used for local effects extensively in decongestant and local activity. But, in recent times intranasal drug delivery is being considered as a preferred route of drug delivery for systemic bioavailabilityVarious proteins & peptides have shown a good bioavailability
4Intranasal Drug Delivery System: Advantages Its easy and convenientCan be easily administered to the unconscious patientsCompared to oral medications, intranasal medication delivery results in:Faster delivery to the blood stream and higher blood levelsNo destruction by stomach acid and intestinal enzymesNo destruction by hepatic first pass metabolismCompared to IV medications, intranasal medication delivery results in:Comparable blood levels depending on the drug and dose.
5Fundamental Factors Affecting Nasal Absorption Molecular weight: Absorption of drugs decreases as the molecular weight of drug molecules increases. Mc Martin et al reported a sharp decline in drug absorption having molecular weight greater than 1000DaltonLipophilicityDrug concentration: Absorption increases as concentration of drug increases. 1-tyrosine shows increased absorption at high concentration in rate..Particle size:Particle size microns adheres best to the nasal mucosa.
6MECHANISMS Two mechanisms are found to be involved: Fast rate mechanism, which is lipophilicity dependent.Slow rate mechanism, which is dependent on molecular weight.Ex: Nasal delivery of insulin, manitol follows a transport mechanism involving passive diffusionWhile, absorption of water soluble molecules like sodium cromoglycate take place by diffussion through aqueous pores
8DELIVERY SYSTEMS Various delivery systems are used like Nasal spray Nose dropsAerosol sprayMetered dose nebulizerSaturated cotton pledgetThe insufflatorsMucosal atomizer device (M.A.D)Microspheres
9ENHANCEMENT IN ABSORPTION Use of absorption enhancersIncrease in residence timeAdministration of drugs in the form of microspheresVarious enhancers usedSurfactantsPhospholipidsChelatersGlycolsCyclodextrinsCapable of increasing membrane fluidity and leaching of proteins and lipids from the membrane
10Applications of Intranasal Drug Delivery Nasal Delivery of Organic based Pharmaceuticalse.g.: Progesterone, Estradiol, Testosterone, Hydralzine, Propranolal, Cocain, Naloxon & Nitrogylcerine. These have shown good Bioavailability by this route.Water-soluble organic based compounds such as Sodium cromoglycate were also found to be well absorbed.Nasal Delivery of Peptide-Based DrugsAs peptide based drugs are susceptible to hepatogastrointestinal first pass elimination & instability, they show very low oral bioavailability thus administered through nasal route.
11EXAMPLES SHOWING DIFFERENT DELIVERY SYSTEMS MUCOSAL AUTOMIZATION DEVICE (M.A.D)TRADITIONAL & KURVE’S DELIVERY
12EXAMPLES INTRANASAL Naloxone Accuspray from BD Medical–Pharmaceutical Systems is a single-use nasal sprayer for monodose or bidose administration INTRANASAL Naloxone
13ConclusionsNDDS provides route of drug administration for drugs, which degrade due to first pass metabolismThough it also poses many challenges such as low absorption, toxicological problems, high dose requirements etc.,, thus use of absorption enhancers is proving to be useful increasing the absorption.Insulin is being extensively investigated for its nasal absorption, which may prove a major turnaround in diabetic’s treatment.With ongoing efforts to improve bioavailability of protein and peptide drug through nasal route, the nasal route can become the prime route for administration of protein drugs..
14REFERENCES Shaji J and Marathe S.W. NASAL DRUG DELIVERY SYSTEM: OPPORTUNITIES & CHALLENGESINDIAN DRUGS Vol. 45 No. 5May Pg no (345 – 353)