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A FR-1FR-3FR-6 0 150 300 450 600 Active nose-poke * *** b 0 25 50 75 100 DI (%) * ** c 0 20 40 60 80 Food pellet ** Suppl. Fig. 1 Suppl. Fig. 1 CD-1 mice.

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Presentation on theme: "A FR-1FR-3FR-6 0 150 300 450 600 Active nose-poke * *** b 0 25 50 75 100 DI (%) * ** c 0 20 40 60 80 Food pellet ** Suppl. Fig. 1 Suppl. Fig. 1 CD-1 mice."— Presentation transcript:

1 a FR-1FR-3FR-6 0 150 300 450 600 Active nose-poke * *** b 0 25 50 75 100 DI (%) * ** c 0 20 40 60 80 Food pellet ** Suppl. Fig. 1 Suppl. Fig. 1 CD-1 mice rapidly acquire food-driven operant behaviour. (a) Active nose-pokes, (b) discrimination index (DI, active nose-pokes/total nose-pokes X 100) and (c) food pellets eaten during the nine daily sessions of the fixed ratio (FR) reinforcement schedules (FR-1, FR-3 and FR-6). Values represent mean±s.e.m. N=16. *P<0.05, **P<0.01, versus FR-1 days. ***P<0.001, versus FR-3 days.

2 0 30 60 90 120 BP a 0 25 50 75 100 DI (%) b 0 600 1200 1800 2400 Horizontal activity c 0 200 400 600 800 Vertical activity d CTLOW B 20 Morphine (mg/kg, i.p.) 406080100 * B 20 Morphine (mg/kg, i.p.) 406080100 Suppl. Fig. 2 Suppl. Fig. 2 Early (8-hour) opiate withdrawal does not affect food-driven operant behaviour. (a) Breakpoint (BP), (b) discrimination index (DI, active nose- pokes/total nose-pokes X 100), (c) horizontal and (d) vertical activity displayed by control (CTL) or opiate-withdrawn (OW) mice during the baseline days (B) and the interval between successive morphine injections. Values represent mean±s.e.m. N=8/group. *P<0.05, versus CTL mice.

3 Suppl. Fig. 3 Suppl. Fig. 3 Body weight (BW) rapidly recovers following opiate withdrawal. BW changes, calculated as percentage of BW recorded just prior to the first saline or morphine injection, displayed by control (CTL) or opiate-withdrawn (OW) mice during the morphine (20-100 mg/kg, i.p.) dosing days and 24-120 hours following opiate withdrawal. BW is recorded 12 hours after the second injection of the morphine dose indicated. Values represent mean±s.e.m. N=8group. **P<0.005, versus CTL mice. Notably, by 24 hours after cessation of morphine dosing no more opiate withdrawal effect is observed.


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