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Miglitol 150 mg per day Biphasic Insulin aspart M16U, E4U M16U Insulin glargine M8U Glimeperide 1mg Voglibose 0.6 mg Hospitalization Flare, Itching, swelling.

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Presentation on theme: "Miglitol 150 mg per day Biphasic Insulin aspart M16U, E4U M16U Insulin glargine M8U Glimeperide 1mg Voglibose 0.6 mg Hospitalization Flare, Itching, swelling."— Presentation transcript:

1 Miglitol 150 mg per day Biphasic Insulin aspart M16U, E4U M16U Insulin glargine M8U Glimeperide 1mg Voglibose 0.6 mg Hospitalization Flare, Itching, swelling at injection site HbA1c 6 7 8 9 1/12/1 3/ 4/15/16/17/18/19/110/1 HbA1c(%) 2009 Hypoglycemic symptoms AprilMayJuneJulyAug JanFebMarSep 000710 123 1 BS (17:30) >160 75 262425 202 Fig. S1

2 Fig. S2 k 1 =2.94×10 -3 1/10 - 8 M b 1 =214 10 - 8 M k 2 =4.49×10 -5 1/10 -8 M b 2 =515 10 - 8 M

3 0 5050 10 0 15 0 20 0 25 0 30 0 35 0 Plasma Glucose (mg/dl) day10 0 5050 10 0 15 0 20 0 25 0 30 0 35 0 day 2 Biphasic insulin aspart 16 Units Miglitol 150mg Insuli glargine 8 Units Miglitol 150 mg Glimeperid 1mg 7:3010:0012:0015:0017:3020:0022:003:007:30 Fig. S3

4 UrinalysisBlood ChemistryData related Diabetes pH5.5AST18 U/mlFBS108 mg/dl Pro-ALT17 U/mlHbA1c (NSPG equivalent)8.9% Glu3+LDH180 U/mlTotal IRI967 μU/ml bil-ALP276 U/mlFree IRI9.7 μU/ml ket-γ-GTP20 U/mlCPR1.26 ng/ml ob-BUN20.6 mg/dlTSH1.55 μU/ml uro-Crn1.10 mg/dlFT41.02 ng/dl U-CPR88 μg/dayNa140 mEq/l K4.6 mEq/lImmunochemistry Blood countCl105 mEq/lInsulin antibody>90% WBC7570/μlT.Chol193 mg/dlInsulin IgE2.02 (score2) RBC430x10 4 /μlTG73 mg/dl Hb12.9 g/dlHDLc46 mg/dlScatchard analysis of anti-insulin antibodies Ht39.60%k1=2.94x10 -3 (1/10 -8 M) Plt15.9x10 4 /μlHLA haplotypeb1=214 (10 -8 M) HLA-DRB1:*140101/*080302k2=4.49x10 -5 (1/10 -8 M) b2=515 (10 -8 M) Table S1. Laboratory data on admission

5 Table. S2 Skin prick test against human insulin and insulin analogues histamine 10 10x8 saline 0 0x0 NovoRapid30mix ® (insulin aspart, glycerol, m-cresol, phenol, Na 2 HPO 4, protamine) 3 4 5x4 Lantus ® (insulin glargine, m-cresol, glycerol) 0 3x3 Humalin R ® (human insulin, m-cresol, glycerol) 3 4 6x6 Humalin N ® (human insulin, NaH 2 PO 4, m-cresol, phenol, glycerol, protamine) 4 5 5x5 Humalog N ® (insulin lispro, NaH 2 PO 4, m-cresol, phenol, glycerol) 4 5x4 Humalog Mix25 ® (insulin lispro, NaH 2 PO 4, m-cresol, phenol, glycerol) 3 5x5 Humalog ® (insulin lispro, NaH 2 PO 4, m-cresol, phenol, glycerol) 0 5x4 Humalog Mix50 ® (insulin lispro, NaH 2 PO 4, m-cresol, phenol, glycerol) 0 5x6 15min 20min Flare (mm)


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