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MMX™ Multi Matrix System Presentation

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1 MMX™ Multi Matrix System Presentation

2 Disclaimer Important Notice
For the use of the recipient only. Not to be copied or distributed to any other person. This presentation has been prepared from publicly available information, internally developed data and other sources believed to be reliable. No representation, warranty or undertaking (express or implied) is given and no responsibility is accepted by Cosmo or by any of its officers, employees or agents for the completeness or accuracy of any information contained in, or of any omissions from, this presentation or any supplementary information made available to any interested party or its advisers, and any liability in respect of such information or omissions is hereby expressly disclaimed. This presentation does not constitute an offer, invitation or recommendation to buy, sell, subscribe for or issue any securities or a solicitation of any such offer or invitation and shall not form the basis of any contract with Cosmo. Opinions expressed herein are subject to change without notice. In providing this presentation, Cosmo undertakes no obligation to provide the recipient with access to any further information or to correct any inaccuracies or omissions which may become apparent.

3 Drug Delivery Platform
New oral delivery technology Designed for off-patent drugs Focus on inflammatory bowel diseases Scaleable/low cost of goods

4 The Drug Delivery Platform
Multi Matrix System™ (MMX ™) Inert matrix Hydrophilic matrix Gastroprotectant layer LV hydrophilic - amphipatic polymer matrix HV hydrophilic polym. matrix inert matrix material drug (+ excipient)

5 MMX™ - Release of active ingredient
stomach Duodenum Dejunum % Ileum Colon Time

6 IBD medications: sites of action MMX™ tablets vs. other dosage forms
Site of action Oral dosage forms enemas MMX ™ tablets

7 1h 30’ small intestine 3h 30’ ileum 4h 30’ ascending colon 7h 30’ trasverse colon 10h trasverse colon 15h descending colon

8 MMX™ 16h descending colon 24h rectum

9 MMX™ Low absorption after single dose administration in Drug (•) and Metabolite (o)

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