1. Chapter 53 Chapter 53 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis Copyright © 2013 Elsevier Inc. All rights reserved.

2. FIGURE 53.1 Collagen biosynthesis. 2

3. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.2 Osteogenesis imperfecta type I. 3

4. Copyright © 2013 Elsevier Inc. All rights reserved. 4 FIGURE 53.3 Blue sclerae in osteogenesis imperfecta.

5. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.4 Triangular facies in osteogenesis imperfecta. 5

6. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.5 Osteogenesis imperfecta type I. 6

7. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.6 Osteogenesis imperfecta type II. 7

8. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.7 A and B 8

9. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.8 Osteogenesis imperfecta type III. 9

10. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.9 Osteogenesis imperfecta type III. 10

11. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.10 Osteogenesis imperfecta type IV. 11

12. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.11 Osteogenesis imperfecta type V. 12

13. Copyright © 2013 Elsevier Inc. All rights reserved. FIGURE 53.12 Osteogenesis imperfecta type VII, (A) Patient age 3 years 5 months, showing selective shortening of the humeri (rhizomelia). (B) Patient V-6, age 4 months, showing bilateral coxa vara. Bowing deformity of the lower extremities is also evident. Source: Ward et al. (2002) [80]. 13

14. Copyright © 2013 Elsevier Inc. All rights reserved. 14 FIGURE 53.13 Osteogenesis imperfecta type VIII.