FIGURE 12.1 Relationship between plasma levels of ionized calcium and the release of parathyroid hormone (PTH)(1-84) in normal humans. Variations in plasma ionized calcium were achieved by the infusion of calcium or ethylenediaminetetraacetic acid (EDTA). Note the sigmoidal relationship, ensuring significant changes in PTH secretion with small variations in ionized calcium. Source: reproduced from Brown (1991) , with permission. 2
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