1. The Strategic Moment Big Pharma spends heavily on R&D Big Pharma projects global sales out: >>> 2010 $600 billion >>> 2020 $1,200 billion Big Pharma net income ~ 20 - 30% on sales

2. The Strategic Moment Big Pharma R&D spending rises, results elusive

3. The Strategic Moment Big Pharma looks to increased outsourcing of R&D to speed drug discovery to convert fixed costs into variable costs to tap the large pool of world class talent in science and technology in China, India, Russia

4. 19931.6 19952.4 19973.6 19995.5 20017.0 20039.3 The Strategic Moment Growth of the Contract Research Market for outsourcing drug discovery R&D (billion US$)

5. The Strategic Impasse Big Pharma looks to increased outsourcing of R&D Big Pharma sees the large pool of world class talent in science and technology in China, India, Russia Big Pharma sees the tremendous cost-advantages potentially realizable by doing more in China, India, Russia Big Pharma have no visibility into CROs in China, India, Russia Outsourcing projects are a notorious headache to manage Cannot see into the Black Box Cannot solve the mutual trust and communication issue Cannot solve the day-to-day fine-grained project tracking issues

6. Breaking through the Strategic Impasse: China Big Pharma sees world class talent in science and technology in China with tremendous cost advantages there The solution: CalenTrack as the fine-grained off-site research management tool The Unique Node to let Big Pharma see inside the Black Box The Unique Node matches projects needs of Big Pharma with top- talent CROs within China CalenTrack guarantees transparency, total tracking China is a Black Box to Big Pharma Who can we deal with? Who can we trust?

7. Breaking through the Strategic Impasse: China Big Pharma sees world class talent in science and technology in China with tremendous cost advantages there The solution: CalenTrack as the fine-grained off-site research management tool The Unique Node to let Big Pharma see inside the Black Box The Unique Node matches projects needs of Big Pharma with top- talent CROs within China CalenTrack guarantees transparency, total tracking CalenTrack is a tool to protect IP rights

8. Big Pharma Need to outsource more research Need to find reliable capable CROs CHINA A BLACK BOX Fear factors: Business culture Knowing who is who Whom do I trust? How do I get things done?

9. Big Pharma research needs The Unique Node with CalenTrack trusted CRO CHINA with good connections: a deep well of talent

10. CalenTrack lets you see inside the Black Box CalenTrack solves the fine-grained project tracking issues CalenTrack enables managers to respond quickly to follow promising leads and to correct mistakes in good time. Using CalenTrack enables closer tracking and targetting of effort, with the result that you get more done with fewer researchers.

11. CalenTrack makes the CRO team transparent CalenTrack enables communication with a decentralized team that is precisely focused on specific data and research findings. CalenTrack puts all data files created by the team where they can be seen and shared. Using CalenTrack the off-site manager can track at a glance individual contributors, their time spent by task, and their progress against milestones. With CalenTrack the manager can keep a close eye on the big picture at the project level, encompassing the project team, the project data, and project supplies.

12. CalenTrack is a tool for improving CRO performance CalenTrack is a tool for building mutual trust Using CalenTrack enables closer tracking of CRO performance. Companies employing contract research organizations around the world will be able to oversee their operations in detail, and compare and rate their performance with precision. High-performing contract research organizations using CalenTrack can establish a track record documenting their superior performance, and establish their credentials as preferred service providers. Both sides gain – mutual trust unblocks the deal flow

13. CalenTrack IP Vault™ holds a secure fine-grained record to verify to all IP claims CalenTrack is a tool for safeguarding IP rights CalenTrack builds a detailed record of all work done by the research team. CalenTrack builds a comprehensive record of what work was done when, and by whom, including all data files, and communications threads among the team members.

14. CalenTrack is a full featured tool for research management Manage performance Manage communications Manage time constraints Manage inventory Manage costs Track project task history Track working hours Track IP issues Control deadlines Monitor productivity Monitor budgets Identify problems and risks Generate daily, weekly and monthly reports Document results, e-archiving Built-in search engine Quick access to user-selected databases