1. Supporting Life Scientists via End User Programming Luke Church Computer Laboratory, University of Cambridge Microsoft eScience - Dec 08 With thanks to co-authors:

2. Agenda End User Programming (EUP) –What is it? –How is it being used? Supporting Scientists 1: Usability –Applying EUP to improve our tools –State of the art: Cognitive Dimensions of Notations 2: Executable Biology: Life as Computation –Successes –Challenge: natural abstractions

3. End User Programming? Direct Manipulation Programming Actions on objects Actions on lots of objects Actions when Im not here Communicating intent Abstraction Mainstream Usability Professional Programmers End User Programming End Users Power, Expressiveness, Communication Current UI paradigm

4. End Users Can Program A few million users... Given the right problem and tools

5. End Users Can Program Given the right problem and tools

6. End Users Can Program Given the right problem and tools (From http://blogoscoped.com/archive/2007-02-10.html)

7. End Users Can Program Given the right problem and tools

8. Why give EUP a name? Programming is a different cognitive task –Direct Manipulation usability methods dont help much Reasonable from a direct manipulation perspective But has Hidden Dependencies poor Provisionality poor Progressive Evaluation etc.

9. Why give EUP a name? Programming is a different cognitive task –EUP analysis tools acknowledge this By understanding that something is programming Improved design discussions Text or graphics? Impact of type systems? More appropriate usability techniques Cognitive Dimensions of Notations Attention Investment Framework User Experience of Intentional Information

10. EUP for life Scientists 1: Usability

11. Modelling tools A particular type of programming language –We used analytical EUP techniques to improve usability –Small user study showed a good provisional result –Prototype now in refinement

12. Cognitive Dimensions State of the art usability technique –Consider an environment, along a number of dimensions –How defuse is the information? –How viscous is it? –How many abstractions does the user have to learn? –Does the user have to prematurely commit to a structure? –Highlight areas of likely problems, suggest design manoeuvres

13. Cognitive Dimensions

14. Successes Identify and fix deep usability problems Academically verified and supported 50+ extension papers, widely cited within community Theoretical testing, practical adoption Workshops, tutorials, handbook in progress Increasing adoption Scientific tools API design at Microsofts Security usability Spreadsheet UI design...

15. EUP for life Scientists 2: Executable Biology

16. Executable Biology Executable models of living processes Compare predictions to data Suggest new experiments Adjust model

17. Executable Biology Successes –Experimentally verified refinements in regulatory models of various organisms –Proposed new concurrency models to reflect biological processes –Successful application of formal verification techniques to laboratory data Challenges –Challenges laboratory practice around timed measurements in experiments –Develop computational models that are more suitable for biological modelling

18. Executable Biology New Abstractions? –Need for abstraction processes that work with biology –Translucent, socially supported, computationally tractable –Abstraction problem in computers, let alone biology –Possibility for great mutual benefit What does it mean to understand a program? –Pragmatic computationalism, it is useful to consider: life computational model –What does it mean to understand a program independent of a goal?

19. On Abstraction... Abstraction carries Intention –Classifications/Abstractions are a shaping perspective –E.g. International Classification of Disease –Abstracting biological systems => shaping what we can know –What questions are interesting? –Traditionally decided by the scientific community Accelerating time to discovery? –We are deciding what questions are answerable –Adoption requires supporting social processes –Responsibility to make answers useful

20. Summary Usability Usability is crucial to adoption and efficiency Standard techniques: necessary but not sufficient End User Programming techniques help Executable Biology Pragmatic computationalism Understand living systems like programs, positive initial results Deeper challenges What does biology mean by understand? Provide new abstraction processes, with social support Accelerating discovery by providing new ways of thinking about biological systems