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Published byNicholas Pierce
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Segmentation outward inward
Three Conformations Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop muscle (PDB - 1QVI) F-actin pre-power stroke state in smooth muscle (PDB - 1BR1)
CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41 outward inward Docking by SITUS (colores) ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke
outward inward ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke Docking by SITUS (colores) CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41
CC= 0.64 outward Docking by SITUS (myoV-ADP) ADP myosin-V
CC= 0.82 outward Normal Mode Flexible Fitting (myoV-ADP) ADP myosin-V
CC= 0.58 Docking by SITUS (scallop-like) outward Scallop-like pre- power stroke
CC= 0.77 Normal Mode Flexible Fitting (scallop-like) outward Scallop-like pre- power stroke
Fitted scallop-like on F-actin F-actin Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop myosin (PDB - 1QVI) pre-power stroke state in smooth muscle myosin (PDB - 1BR1)
The Contraction Cycle Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc.
Myosin Myosin is a protein molecule found in the thick filaments. Myosin is a protein molecule found in the thick filaments.
The muscular system. Three types of muscle Smooth muscle is an involuntary muscle. Example – digestive system Cardiac muscle is an involuntary muscle.
09_10 Sliding filament theory Slide number: 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Tropomyosin.
Sliding Filament Theory How do muscles work…... Muscle Cell Structure n Muscles are broken into smaller muscle fibers n muscle fibers are broken into.
The Steps of Muscle Contraction: The Sliding Filament Theory.
Excitation-contraction coupling Sliding filament mechanism independent studies by Huxley and Huxley (no relation) in 1954.
Myosin is a motor that runs along (or tugs at) actin. Actin-based movement of vesicles Chromosome migration Myosin-driven cell shape changes Muscle contraction.
Excitation-Contraction Coupling Once generated, the action potential: Is propagated along the sarcolemma Travels down the T tubules Triggers Ca.
Muscle Action Muscle cells are polarized, have charge Excess of Na+ ions in ECF Excess of K+ ions in ICF mixed with PO 4 -3 cause muscle fiber to have.
IN CLASS NOTES = STEPS OF A MUSCLE CONTRACTION. STEP 1 Calcium ions present Ca+ binds to troponin which makes tropomyosin move out of way for myosin head.
1 Skeletal muscle structure fig 9-1a striated long multinucleate cells extend from tendon to tendon formed by fusion of myoblasts innervated by somatic.
Warm-Up 4/8/15 1.What is an autoimmune disorder? 2.What how are LEMS and MG similar? 3.How are LEMS and MG different? Test - Tuesday.
Muscles. Muscles work by contracting. Muscles pull. A pair is needed to move a bone two ways. An antagonistic pair.
Sliding Filament Theory Myosin heads attach to and “walk” along the thin filaments pulling the thin filaments towards the M line thin filaments are.
1 Non Deterministic Automata. 2 Alphabet = Nondeterministic Finite Accepter (NFA)
Outline I. Types of Muscle II. Anatomy of Skeletal Muscle III. Sliding Filament Theory IV. Role of Ca+ in regulating muscle contraction.
Muscle Review. Myosin Actin What separates a sarcomere? Z – lines (disc)
Motor Proteins. One-state model with unequal forward and backward rates.
Hair cells, actin bundles, and unconventional myosins.
Synapse – The site of connection between a neuron and a cell. Neurotransmitter – A chemical released at the neuron’s synapse that communicates with the.
Bellringer 12/9 Label #4 and #5. Building Skeletal Muscle… We will identify the different structures within a skeletal muscle by building a model.
The Sliding Filament Theory. Steps to the Sliding Filament Theory 1.A message originates in the brain and is released to the central nervous system (CNS)
Question 1 Explain the primary differences between smooth, skeletal, and cardiac muscle tissue Skeletal muscle fibers are cylindrical, multinucleate cells,
Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere.
Week 1 Click images for hyperlinks!. What is a muscle? Muscles are organs made of muscular and connective tissues, which make up the Muscular System They.
1 Hole’s Human Anatomy and Physiology Twelfth Edition Shier Butler Lewis Chapter 9 Muscular System Copyright © The McGraw-Hill Companies, Inc. Permission.
Filaments Resting state Electrical impulse (Action Potential) reaches axon terminal.
How do muscle cells contract ?. What is the structure of a muscle fiber ? The sarcolemma, or plasma membrane contains invaginations called T (transverse)
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