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Segmentation outward inward
Three Conformations Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop muscle (PDB - 1QVI) F-actin pre-power stroke state in smooth muscle (PDB - 1BR1)
CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41 outward inward Docking by SITUS (colores) ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke
outward inward ADP myosin-V Scallop-like pre- power stroke smooth muscle-like pre-power stroke Docking by SITUS (colores) CC= 0.64CC= 0.53 CC= 0.42 CC= 0.58 CC= 0.42 CC= 0.41
CC= 0.64 outward Docking by SITUS (myoV-ADP) ADP myosin-V
CC= 0.82 outward Normal Mode Flexible Fitting (myoV-ADP) ADP myosin-V
CC= 0.58 Docking by SITUS (scallop-like) outward Scallop-like pre- power stroke
CC= 0.77 Normal Mode Flexible Fitting (scallop-like) outward Scallop-like pre- power stroke
Fitted scallop-like on F-actin F-actin Myosin-V with ADP (PDB - 1W7I) pre-power stroke state in scallop myosin (PDB - 1QVI) pre-power stroke state in smooth muscle myosin (PDB - 1BR1)
The Contraction Cycle Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc.
Sliding Filament Theory How do muscles work…... Muscle Cell Structure n Muscles are broken into smaller muscle fibers n muscle fibers are broken into.
09_10 Sliding filament theory Slide number: 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Tropomyosin.
Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere.
Midterm Review Part II Midterm Review Part II 40.
IN CLASS NOTES = STEPS OF A MUSCLE CONTRACTION. STEP 1 Calcium ions present Ca+ binds to troponin which makes tropomyosin move out of way for myosin head.
Myosin Myosin is a protein molecule found in the thick filaments. Myosin is a protein molecule found in the thick filaments.
Muscle Contraction. Message 1. Nerve sends impulse to muscle; neuromuscular junction 2. End of nerve releases chemical Acetylcholine (Ach)
Muscle. 3 Types of muscle Smooth- line the walls of internal organs and blood vessels. Involuntary movement. Skeletal- striated, allow for movement, voluntary.
Sliding Filament Theory Myosin heads attach to and “walk” along the thin filaments pulling the thin filaments towards the M line thin filaments are.
The muscular system. Three types of muscle Smooth muscle is an involuntary muscle. Example – digestive system Cardiac muscle is an involuntary muscle.
Muscle Review. Myosin Actin What separates a sarcomere? Z – lines (disc)
The Steps of Muscle Contraction: The Sliding Filament Theory.
Addition and Subtraction Equations
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©2004 by Pearson Education11-1 R.C. Hibbeler Resistência dos Materiais, 5ª ed. 11 – Projetos de Vigas e Eixos.
Hair cells, actin bundles, and unconventional myosins.
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Week 1 Click images for hyperlinks!. What is a muscle? Muscles are organs made of muscular and connective tissues, which make up the Muscular System They.
Chapter 12 Static Equilibrium; Elasticity and Fracture Physics for Scientists & Engineers, 3 rd Edition Douglas C. Giancoli © Prentice Hall.
Muscle Action Muscle cells are polarized, have charge Excess of Na+ ions in ECF Excess of K+ ions in ICF mixed with PO 4 -3 cause muscle fiber to have.
GET A BOOK. GET OUT YOUR HOMEWORK. TUESDAY, NOVEMBER 17, 2015.
CHAPTER 18 The Ankle and Lower Leg
Muscle fiberMotor neuron Nucleus. SarcolemmaMyofibrils Sarcoplasmic reticulum (SR) T-tubule SR Cistern.
Skeletal Muscle Contraction Sliding Filament Model actin myosin Fig
Myosin is a motor that runs along (or tugs at) actin. Actin-based movement of vesicles Chromosome migration Myosin-driven cell shape changes Muscle contraction.
Ch. 11 pg 290. The movement in humans involves bones, ligaments, muscles, tendons and nerves.
Question 1 Explain the primary differences between smooth, skeletal, and cardiac muscle tissue Skeletal muscle fibers are cylindrical, multinucleate cells,
WARM UP 1.List 10 locations in the body you can find muscle.
MUSCLE CONTRACTION. Microscopic Anatomy of Skeletal Muscle Sarcomere Contractile unit of a muscle fiber Figure 6.3b.
Everything you didn’t know you wanted to know.. Microscopic Anatomy of Skeletal Muscle Sarcolema: Plalsma membrane of cell (fiber) Myofibril: Organelle.
Muscles. Muscles work by contracting. Muscles pull. A pair is needed to move a bone two ways. An antagonistic pair.
Copyright © 2007 The McGraw-Hill Companies Inc. Permission Required for Reproduction or Display. Basic Weight Training Weight Training and Your Body Chapter.
Section 9.3 Muscle Contraction. Neuromuscular Junction.
Notes: Sliding Filament Theory [Muscle Contraction Physiology]
Warm-Up 4/8/15 1.What is an autoimmune disorder? 2.What how are LEMS and MG similar? 3.How are LEMS and MG different? Test - Tuesday.
General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - https://commons.wikimedia.org/wiki/File:Smooth_muscle_tissue.jpg#/me.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Twitch time course Duration of twitch is largely governed by rate of sequestration.
Movements – - voluntary – intend to make; ex. walking - involuntary – you do not control; ex. breathing.
Outline I. Types of Muscle II. Anatomy of Skeletal Muscle III. Sliding Filament Theory IV. Role of Ca+ in regulating muscle contraction.
THE NATIONAL GALLERY STRUCTURE CHART As at 30 JUNE 2010.
1 Skeletal muscle structure fig 9-1a striated long multinucleate cells extend from tendon to tendon formed by fusion of myoblasts innervated by somatic.
Bellringer 12/9 Label #4 and #5. Building Skeletal Muscle… We will identify the different structures within a skeletal muscle by building a model.
1 When you see… Find the zeros You think…. 2 To find the zeros...
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Muscular Control of Movement. Review of Anatomy Types of Muscles –Smooth: blood vessels and organs –Cardiac: heart –Skeletal: muscles for movement.
Excitation-Contraction Coupling Once generated, the action potential: Is propagated along the sarcolemma Travels down the T tubules Triggers Ca.
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