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Supplementary Figure 1 a b RANK 1 2 3 4 5 6 7 8 9 10 11 * RANK Arbitrary Score ns 0 1 2 3 Normal breast Primary tumor Metastasis lymph node *

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Presentation on theme: "Supplementary Figure 1 a b RANK 1 2 3 4 5 6 7 8 9 10 11 * RANK Arbitrary Score ns 0 1 2 3 Normal breast Primary tumor Metastasis lymph node *"— Presentation transcript:

1 Supplementary Figure 1 a b RANK * RANK Arbitrary Score ns Normal breast Primary tumor Metastasis lymph node *

2 ac d Supplementary Figure 2 Day 3Day 1 3 H thymidine uptake (CPM) RANKL RANKL / OPG Control Anisomycin Control UV Sorbitol % survival RANKL Control RANKL Prolactin pERK1/2 pAKT AKT pSTAT5 STAT min pERK1/2 -Actin ERK1/2 RANKL min RANK b e

3 Supplementary Figure 3 % increased migration RANKL [1 g/ml] RANKL [2.5 g/ml] SDF-1 [0.1 g/ml] RANKL [2.5 g/ml] SDF-1 [1 g/ml] RANKL [2.5 g/m]

4 a bc Migration toward the tip, mm Control RANKL OPG * Supplementary Figure 4 ControlRANKL ControlRANKL

5 RANK -actin 12 c RANKL RANKL / OPG RANKL / -CXCR4 SDF-1 -CXCR4 SDF-1 OPG SDF % increased migration * * Supplementary Figure 5 a ERK1/2 RANKL SDF min min pERK1/2 d b % migration % increased migration SDF-1 RANKL 6Ckine 6Ckine / RANKL CTACK CTACK / RANKL SDF-1 / RANKL * *

6 Supplementary Figure 6 a c TibiaVertebra TumorControl b * Total Trabecular Cortical Bone density (pQCT mg/cm 3 ) Control B16F10

7 Supplementary Figure 7 ControlTumorTumor / OPG * * abc def ghi * *


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