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Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling.

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Presentation on theme: "Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling."— Presentation transcript:

1 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest No Wnt signaling

2 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest ß-catenin recruitment and phosphorylation

3 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest ß-Trcp binding and ß-catenin degradation

4 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Downstream gene expression inhibited

5 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Wnt signaling

6 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Activation of Disheveled and inhibition of ß-catenin degradation

7 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Formation of LEF/TCF transcriptional complex

8 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Downstream gene expression activated

9 Laboratory Investigation advance online publication 8 January 2007; doi: /labinvest Crosstalk between Wnts and other pathways


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