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Mdm4 Mdm2 HAUSP 1: BT202: BT4744: BT5495: CAMA-1 6: DU4475 7: EVSA-T 8: HCC19379: Hs578T p53 p300 pRB ATM CBP p16 p21 p14ARF Tropomysosin Tubulin PUMA.

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Presentation on theme: "Mdm4 Mdm2 HAUSP 1: BT202: BT4744: BT5495: CAMA-1 6: DU4475 7: EVSA-T 8: HCC19379: Hs578T p53 p300 pRB ATM CBP p16 p21 p14ARF Tropomysosin Tubulin PUMA."— Presentation transcript:

1 Mdm4 Mdm2 HAUSP 1: BT202: BT4744: BT5495: CAMA-1 6: DU4475 7: EVSA-T 8: HCC19379: Hs578T p53 p300 pRB ATM CBP p16 p21 p14ARF Tropomysosin Tubulin PUMA CDK4 Cyclin D1 10: MCF-712: MDA-MB-15711: MDA-MB-134VI13: MDA-MB-175VII14: MDA-MB-23115: MDA-MB-33016: MDA-MB-36117: MDA-MB-41518: MDA-MB-435S19: MDA-MB-43620: MDA-MB-45321: MDA-MB B: OCUB-M22: MPE60024: SK-BR-325: SK-BR-526: SK-BR-7 27: SUM44PE28: SUM52PE30: SUM149PT31: SUM159PT32: SUM185PE33: SUM190PT 34: SUM225CWN 35: SUM229PE36: SUM1315M02 37: T47D38: UACC-81239: UACC-89340: ZR75-141: ZR75-30 Supplementary Figure 1

2 CD AB Supplementary Figure 2 *** ** * *** ** *** * ** *** * ** ***

3 Supplementary Figure 3 A DC B

4 Mdm2 Mdm4 pSer15-p53 pSer46-p53 p53 PUMA p21 HAUSP Doxorubicin + 10 µM Nutlin-3 Supplementary Figure 4


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