Presentation is loading. Please wait.

Presentation is loading. Please wait.

Guinea: Low Cost Approaches to Reducing the Disease Burden from Contaminated Groundnuts Paul C. Turner Maryland Institute for Applied Environmental Health.

Similar presentations


Presentation on theme: "Guinea: Low Cost Approaches to Reducing the Disease Burden from Contaminated Groundnuts Paul C. Turner Maryland Institute for Applied Environmental Health."— Presentation transcript:

1 Guinea: Low Cost Approaches to Reducing the Disease Burden from Contaminated Groundnuts Paul C. Turner Maryland Institute for Applied Environmental Health THIS WORK WAS SUPPORTED BY A GRANT FROM THE NIEHS, USA ES06052

2

3

4 Aflatoxins in Foods from 4 Villages in Lower Guinea - Nov/Dec Food samples Villageno. positive (%) PeanutsRiceCorn Bangouya9/13 (69)0/151/3 (33) Sougueta5/9 (56)0/141/3 (33) Kolente8/9 (89)0/190/3 Friguiagbe6/15 (40)0/180/0 Total28/46 (61)0/662/9 (22) Other foods all negative for aflatoxins (soup, sorghum, manio, fonio, milk, potato leaves)

5 Clinical Trials Aflatoxin Prevention Studies Primary Prevention Chemoprevention Reduction in aflatoxin exposure Africa and China

6

7 Guinea Intervention Study InterventionControl Groundnut drying Mat150 (100%) 10 (7%) Ground 79 (53%) Mixed 61 (41%) Hand sorting 150 (100%)52 (35%) Type of bag Natural fibre 150 (100%) 4 (3%) Plastic 107 (71%) Mixed 39 (26%) Wood pallet 150 (100%) 6 (4%) Other70 (47%) None 74 (49%) Insecticide use150 (100%)19 (13%)

8

9 Guinea Intervention Study InterventionControl Groundnut drying Mat150 (100%) 10 (7%) Ground 79 (53%) Mixed 61 (41%) Hand sorting 150 (100%)52 (35%) Type of bag Natural fibre 150 (100%) 4 (3%) Plastic 107 (71%) Mixed 39 (26%) Wood pallet 150 (100%) 6 (4%) Other70 (47%) None 74 (49%) Insecticide use150 (100%)19 (13%)

10 Multivariable models of serum AF-albumin at the two follow-up surveys Survey 2 Survey 3 GM ( 95% CI ) GM ( 95% CI )) Individual level intervention12.7 ( 7.8, 20.7) 8.0 (6.1,10.5)** control15.5 (9.5,25.0) 18.4 (14.2,24.0) Village mean level intervention12.3 (11.2,13.5)** 8.2 (7.8,8.5)** control17.6 (16.1,19.3) 18.7 (17.8,19.5) Approx 60% reduction ** p<0.001

11 Are there any issues / problems Focus on ground nut – Maize? JIFSAN et al collaborations Whilst cost is low it is not insignificant What is / are the most effective components? What happens to any discarded food items Sustainability Are any INTERVENTION components lost from the system Large educational components

12 What else?? From year to year will there be added benefit from the previous success? What about co-exposures – AF and FB in maize Are interventions that demonstrate etiology in the child health arena needed – are such interventions different in nature to sustainable interventions of a more global nature

13 Acknowledgements Institut Pasteur de Guinée, Kindia, Republic of Guinea Sylla, A. Diallo M University of Leeds, UK Gong, Y, Sutcliffe A.E. IARC, France Wild CP London School of Hygiene & Tropical Medicine, UK Hall AJ


Download ppt "Guinea: Low Cost Approaches to Reducing the Disease Burden from Contaminated Groundnuts Paul C. Turner Maryland Institute for Applied Environmental Health."

Similar presentations


Ads by Google