1. Xenopus laevis@NP_001086064 Gallus gallus@NP_989735 Homo sapiens@NP_002099 Mus musculus@NP_034531 Danio rerio@NP_001082926 Strongylocentrotus purpuratus@XP_788713 Nematostella vectensis@XP_001638927 Tribolium castaneum@XP_975690 Caenorhabditis elegans@NP_509820 Trypanosoma cruzi strain CL Brener@XP_820336 Dictyostelium discoideum AX4@XP_636944 Emiliania_huxleyi@jgi Aureococcus@jgi Phytophtora_soiae@jgi Perkinsus_marinus_EST_chimera Naegleria@EST_chimera Blastocladiella_emersonii_EST_gb_CO9690 Paramecium tetraurelia strain d4-2@XP_001450600 Paramecium tetraurelia strain d4-2@XP_001446384 98 100 Thermoanaerobacter tengcongensis MB4@NP_622497 Bacillus subtilis subsp. subtilis str. 168@NP_391814 Bacillus cereus AH187@ZP_02254895 Staphylococcus aureus subsp. aureus USA300@YP_492730 Streptococcus pyogenes MGAS9429@YP_597519 Fusobacterium nucleatum subsp. nucleatum ATCC 25586@NP_603688 87 70 Ferroplasma acidarmanus fer1@ZP_01709380 Picrophilus torridus DSM 9790@YP_022885 Thermoplasma acidophilum DSM 1728@NP_393722 Thermoplasma volcanium GSS1@NP_111872 93 100 Thermotoga lettingae TMO@YP_001470158 Fervidobacterium nodosum Rt17-B1@YP_001409653 100 98 90 Methylobacterium sp. 4-46@ZP_01845061 Methylobacterium nodulans ORS 2060@ZP_02118122 Xanthomonas oryzae pv. oryzicola BLS256@ZP_02243773 Caulobacter crescentus CB15@NP_419775 Bradyrhizobium japonicum USDA 110@NP_772882 Roseobacter denitrificans OCh 114@YP_683837 Rhodobacter sphaeroides ATCC 17029@YP_001043461 Bartonella quintana str. Toulouse@YP_032311 Brucella abortus biovar 1 str. 9-941@YP_223097 Mesorhizobium sp. BNC1@YP_675522 Rhizobium leguminosarum bv. viciae 3841@YP_771239 86 99 68 100 Burkholderia pseudomallei 668@YP_001059691 Legionella pneumophila str. Lens@YP_126681 Yersinia enterocolitica subsp. enterocolitica 8081@YP_001008235 Pseudomonas fluorescens Pf-5@YP_257551 Pseudomonas putida@P21310 Moritella sp. PE36@ZP_01900130 Vibrio cholerae MZO-3@ZP_01958051 100 96 93 55 Ralstonia solanacearum GMI1000@NP_520767 Ralstonia pickettii 12D@ZP_02006883 68 100 90 Salinibacter ruber DSM 13855@YP_444860 Porphyromonas gingivalis W83@NP_904639 Microscilla marina ATCC 23134@ZP_01687081 100 95 Bdellovibrio bacteriovorus HD100@NP_969546 Myxococcus xanthus DK 1622@YP_631662 Sorangium cellulosum So ce 56@YP_001616726 75 Haloarcula marismortui ATCC 43049@YP_136389 Halobacterium sp. NRC-1@NP_444214 Rhizobium leguminosarum bv. viciae 3841@YP_771249 100 Rubrobacter xylanophilus DSM 9941@YP_643360 Mycobacterium smegmatis str. MC2 155@YP_885575 Streptomyces avermitilis@Q82I33 100 Gloeobacter violaceus PCC 7421@NP_926012 Herpetosiphon aurantiacus ATCC 23779@YP_001547388 Chloroflexus aurantiacus J-10-fl@YP_001634595 90 Ralstonia metallidurans CH34@YP_582386 Salinispora arenicola CNS-205@YP_001536948 Streptomyces globisporus@AAL06680 100 Halorhodospira halophila SL1@YP_001003386 Rhodobacter sphaeroides ATCC 17029@YP_001045124 Rhodobacter sphaeroides 2.4.1@YP_355075 100 Salinibacter ruber DSM 13855@YP_444855 Saccharothrix espanaensis@ABC88669 86 88 100 82 Desulfuromonas acetoxidans DSM 684@ZP_01312278 Flavobacterium johnsoniae UW101@YP_001193461 Cytophaga hutchinsonii ATCC 33406@YP_678729 100 Streptomyces maritimus@AAF81735 Pantoea agglomerans@AAO39102 Vibrionales bacterium SWAT-3@ZP_01815413 100 74 100 Caldivirga maquilingensis IC-167@YP_001541357 Pyrobaculum arsenaticum DSM 13514@YP_001153691 Rubrobacter xylanophilus DSM 9941@YP_644511 Pseudomonas fluorescens PfO-1@YP_346166 Moritella sp. PE36@ZP_01896913 Vibrio splendidus 12B01@ZP_00990963 Photobacterium profundum SS9@YP_131785 Shewanella pealeana ATCC 700345@YP_001503739 Shewanella baltica OS155@YP_001048738 94 Ralstonia solanacearum GMI1000@NP_521926 Burkholderia vietnamiensis G4@YP_001115140 88 100 Dictyostelium discoideum AX4@XP_644510 Yersinia enterocolitica subsp. enterocolitica 8081@YP_001007210 Photorhabdus luminescens subsp. laumondii TTO1@NP_929491 88 100 Methylobacterium sp. 4-46@ZP_01846502 Herpetosiphon aurantiacus ATCC 23779@YP_001545174 Herpetosiphon aurantiacus ATCC 23779@YP_001544654 Anabaena variabilis ATCC 29413@YP_324488 Nostoc punctiforme PCC 73102@ZP_00105927 100 98 100 Rhodosporidium toruloides@1Y2M_A Rhodotorula mucilaginosa@P10248 Ustilago maydis 521@XP_756225 Lentinula_edodes_EST_gb_EB014275_1 Laccaria bicolor S238N-H82@EDR09035 Amanita muscaria@O93967 Gloeophyllum_trabeum_ESTchimera_gb_EB00 Phanerochaete_chrysosporium_EST_gb|DV76 100 60 Aspergillus oryzae@BAE62292 Magnaporthe grisea 70-15@XP_365191 Phaeosphaeria nodorum SN15@EAT76348 Botryotinia fuckeliana B05.10@XP_001556527 Neurospora crassa OR74A@XP_958734 Aspergillus niger CBS 513.88@XP_001396400 Aspergillus terreus NIH2624@XP_001217749 Aspergillus oryzae@BAE55583 65 100 Gibberella zeae PH-1@XP_389487 Aspergillus niger CBS 513.88@XP_001401803 Aspergillus oryzae@BAE60014 Aspergillus terreus NIH2624@XP_001209308 Aspergillus nidulans FGSC A4@XP_663679 Aspergillus fumigatus Af293@XP_755245 Aspergillus clavatus NRRL 1@XP_001267834 100 99 97 93 85 99 86 66 61 Selaginella kraussiana@AAW80638 Ophioglossum reticulatum@AAW80642 Pellia epiphylla@AAW80645 Equisetum arvense@AAW80639 Isoetes lacustris@AAW80637 Pteridium aquilinum@AAW80644 Pinus pinaster@AAP85251 Pinus sylvestris@AAL74327 Ginkgo biloba@ABZ04127 Huperzia lucidula@AAW80635 Lycopodium tristachyum@AAW80636 Physcomitrella patens subsp. patens@XP_001760495 Psilotum nudum@AAW80640 Botrychium virginianum@AAW80641 Medicago sativa@P27990 Glycine max@P27991 Lotus japonicus@BAF36970 Solanum lycopersicum@P26600 Nicotiana tabacum@P25872 Beta vulgaris@CAH17686 Populus trichocarpa@P45730 Brassica rapa subsp. campestris@ABY89690 Arabidopsis thaliana@NP_181241 Coffea canephora@AAN32866 Manihot esculenta@AAK60274 Agastache rugosa@AAK15640 Lactuca sativa@AAL55242 Petroselinum crispum@P24481 Daucus carota@BAC56977 Vitis vinifera@CAO62112 Vitis vinifera@CAO68933 Zea mays@NP_001105334 Saccharum officinarum@ABM63378 Phyllostachys edulis@ABP96954 Bambusa oldhamii@AAR24505 Triticum aestivum@Q43210 Oryza sativa Japonica Group@NP_001053326 100 87 100 97 92 0.5