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CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association.

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Presentation on theme: "CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association."— Presentation transcript:

1 CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

2 CD40L binds to a distinct binding site within the Mac-1 I-domain. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

3 The peptide inhibitor cM7 specifically interferes with CD40L-Mac-1 binding. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

4 CD40L-Mac-1 interaction drives leukocyte recruitment in vivo. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

5 Specific blockade of the CD40L-Mac-1 interaction attenuates atherosclerosis in mice. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

6 Inhibition of the CD40L-Mac-1 dyad reduces macrophage and lipid accumulation in atherosclerotic lesions. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association

7 CD40L-Mac-1 interaction does not mediate thrombus formation and stability in mice. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association


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