1. Genostar 2009 Genostar Bioinformatics Solutions Connecting, completing and exploring biochemical and genomic data with Metabolic Pathway Builder ChemAxon's User Group Meeting, June 3-4th

2. Genostar 2009 Genostar: about us Located in the heart of the French Alps, near Grenoble Grenoble area Top center for research in France, outside Paris 21,000 researchers 200+ laboratories Strong life sciences research French National Institute for Research in Computer Science and Control (INRIA) Atomic Energy Research Center (CEA) Institute for Structural Biology European Molecular Biology Laboratory (EMBL)

3. Genostar 2009 Genostar: about us Genostar provides bioinformatics software, databases and analysis services for microbial research Applications Vaccine discovery and development Drug discovery Diagnostics Agro-foods Environment

4. Genostar 2009 Our offer: software, data and services Products Metabolic Pathway Builder suite Perform genomic, proteic, and metabolic research with a comprehensive software suite GenoAnnot / ProteoAnnot Perform comparative genomic and proteic sequence annotation and reannotation PathwayExplorer Perform comparative genomic and differential metabolic analyses MicroB Database Integrate, rigorously cross-checked genomic, proteic, biochemical and metabolic data on about 800 organisms KDB Explorer Explore, visualize and highlight the metabolic and non-metabolic pathways specific to your organism PathwayExplorer GenoMirror Local mirror to interactively explore KEGG data while maintaining research confidentiality Services We provide a full range of bioinformatics analysis services

5. Genostar 2009 PathwayExplorer module Draws on heterogeneous data into a powerful entity- relationship model genomic (GenomeReviews, EMBL, Genbank), proteic (Swiss-Prot), classification (Enzyme, GO, NCBI taxonomy…) biochemical (KEGG ligand), metabolic (KEGG pathways), expression data Comparative genomics and metabolomics Integrates proprietary and public methods: EC prediction, pattern inference, homologies and syntons computations… Interactive and specialized viewers Marvin, Jchem Base Interactively explore and visualize metabolic pathways Compare your own data with our reference database

6. Genostar 2009 PathwayExplorer and ChemAxon (1/4) Run Chemaxon structural search e.g: search compounds that contain benzoate substructure Manage and display chemical compounds with Marvin Explore compounds extracted from KEGG ligand database

7. Genostar 2009 PathwayExplorer and ChemAxon (2/4) Find and display biochemical reactions that involve a benzoate derived compound

8. Genostar 2009 PathwayExplorer and ChemAxon (3/4) Colorize reactions that involve benzoate derived compounds Colorize catalyzed reactions Listeria Innocua Bacillus Subtilis

9. Genostar 2009 PathwayExplorer and ChemAxon (4/4) Select a pathway in the KEGG map… … and explore its genomic organization Listeria innocua Bacillus subtilis Compare syntenic regions 1 operon in Bacillus 2 operons in Listeria

10. Genostar 2009 Perspectives Extend Metabolic Pathway Builder capacities further in the direction of cheminformatics Increase connections to external biochemical and chemical databases (ChEBI and UniPathway, PubChem) Integrate 3D facilities (PDB, PubChem, MarvinSpace) Implement structural analysis, predict molecular properties (Calculator Plugins - Chemical Terms) Extend partnerships to increase our capacity in drug discovery and molecular design

11. Genostar 2009 Partners Contact Pierre-Emmanuel Ciron ciron@genostar.com +33 476 97 10 74 Sophie Huet sophie.huet@genostar.com +33 476 97 10 78 Adrienne Kennard adrienne.kennard@genostar.com Thank you info@genostar.com www.genostar.com