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Evidence of Harm 1 EVIDENCE OF HARM – Presentation: Nashville, TN November 11, 2006 David Kirby.

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Presentation on theme: "Evidence of Harm 1 EVIDENCE OF HARM – Presentation: Nashville, TN November 11, 2006 David Kirby."— Presentation transcript:

1 Evidence of Harm 1 EVIDENCE OF HARM – Presentation: Nashville, TN November 11, 2006 David Kirby

2 Evidence of Harm 2 Much of the following information may be found at: WWW.EVIDENCEOFHARM.COM

3 Evidence of Harm 3 AUTISM BY THE NUMBERS: US & EUROPE USA - 1980s: 1-2 per 10,000 children USA - 1980s: 1-2 per 10,000 children Late 1990s: 1 in 500 (2 per 1000) Late 1990s: 1 in 500 (2 per 1000) 2000: 1 in 250 (4 per 1000) 2000: 1 in 250 (4 per 1000) 2004: 1 in 166 (6 per 1000) 2004: 1 in 166 (6 per 1000) 2006: 1 in 175 (5.5 per 1000) ------------- 2006: 1 in 175 (5.5 per 1000) ------------- UK – 2004: 1 in 166 (6 per 1000) Full blown: (2 per 1000) ASD: (4 per 1000) UK – 2004: 1 in 166 (6 per 1000) Full blown: (2 per 1000) ASD: (4 per 1000) Denmark – 2004: 1 in 1,300(0.8 per 1000) Denmark – 2004: 1 in 1,300(0.8 per 1000)

4 Evidence of Harm 4 OTHER POSSIBLE ENVIRONMENTAL TRIGGERS?? Mercury in fish/air/amalgams Mercury in fish/air/amalgams Pesticides Pesticides PCBs PCBs Flame retardants Flame retardants Jet fuel Jet fuel Live virus in vaccines (MMR) Live virus in vaccines (MMR) As-yet unidentified virus As-yet unidentified virus Rampant cell phone use Rampant cell phone use

5 Evidence of Harm 5 KNOW YOUR MERCURY (Hg) TYPE SOURCEEXPOSURE Elemental HgThermometersVapor AmalgamsLights/batteries Inorganic HgUS Coal (40 tons)Air pollutants Chinese Coal CrematoriaJunkyardsVolcanoes Wildfires (800 tons) Organic Methyl HgFishIngestion Organic Ethyl HgThimerosalVaccines AntifungalsParks/tree farms OTC Topicals

6 6 THE "THIMEROSAL GENERATION Maximum Exposure in 1 st year of life - US Schedule - 1992-200? AGESHOTSHG CONTENT BIRTHHep B12.5mcg 8lb infant (3.6kg)– EPA Hg limit: 0.36mcg = 35 times over 4lb infant (1.8kg) – EPA Hg limit: 0.18mcg = 70 times over 2 MONTHSHep B12.5mcg HIb25.0mcg DTaP25.0mcg (subtotal for visit): 62.5mcg Avg. weight: 10lbs/4.5kg EPA limit: 0.45mcg = 138 times over 4 MONTHSHIb25.0mcg DTaP25.0 mcg (subtotal for visit):50.0 mcg Avg. weight: 14lbs/6.5kg EPA limit: 0.65mcg = 72 times over

7 7 Maximum Hg exposure in 1 st year of life - US Childhood Schedule - 1992-200? AGESHOTSHG CONTENT 6 MONTHSHiB25.0mcg DTaP25.0mcg (subtotal for visit):50.0mcg Avg. weight: 16lbs/7.3kg EPA limit: 0.73mcg = 68 times over 12 MONTHS HiB25.0mcg DTaP25.0mcg (subtotal for visit):50.0mcg Avg. weight: 20lbs/9kg EPA Hg limit: 0.9mcg = 55 times over TOTAL Hg EXPOSURE IN FIRST YEAR: 212.5mcg

8 Evidence of Harm 8 EVIDENCE TO SUPPORT THE MERCURY-AUTISM HYPOTHESIS

9 9 ACRODYNIA (PINK DISEASE) Cause: Inorganic Hg used in teething powders Afflicted tens of thousands of children in 1930-1950s. Afflicted tens of thousands of children in 1930-1950s. Symptoms: weepy rash & peeling skin -AND- withdrawal, poor eye contact, poor coordination and muscle control, lethargy, repetitive behaviors, rocking, spastic movements, emotional outbursts, self-injury, sensitivity to light, visual impairments, drooling, insomnia, general ill health. Symptoms: weepy rash & peeling skin -AND- withdrawal, poor eye contact, poor coordination and muscle control, lethargy, repetitive behaviors, rocking, spastic movements, emotional outbursts, self-injury, sensitivity to light, visual impairments, drooling, insomnia, general ill health. 1-in-500 exposed children developed the disease. 1-in-500 exposed children developed the disease. Years passed before mercury poisoning was gradually accepted as the cause, despite stiff resistance by industry. Years passed before mercury poisoning was gradually accepted as the cause, despite stiff resistance by industry. By 1954, most mercury was eliminated from teething powders. Cases fell sharply and then disappeared entirely. By 1954, most mercury was eliminated from teething powders. Cases fell sharply and then disappeared entirely. Today, Pink disease is virtually unheard of. Today, Pink disease is virtually unheard of.

10 Evidence of Harm 10 CHILD WITH ACRODYNIACHILD WITH AUTISM (Mercury poisoning) (Will Redwood)

11 Evidence of Harm 11 INJECTING POISON?

12 Evidence of Harm 12 1991 MSDS – Eli Lilly: Use of chelating agents may be needed to treat ingestion of mercury

13 Evidence of Harm 13 TOTAL Hg BURDEN AND AUTISM RATES IN CALIFORNIA 1985-98

14 Evidence of Harm 14 BOYD HALEY – NEUROTOXICITY Survival rates of neurons after 24 hour exposure to thimerosal, aluminum, antibiotics and testosterone--

15 Evidence of Harm 15 BRADSTREET ET. AL. – Autistic kids excrete 6 times more Hg

16 Evidence of Harm 16 Chelation results from autistic child

17 Evidence of Harm 17 Holmes, Haley and Blaxill Baby Haircut Study 2003 Autistic vs. Controls

18 18 Mady Hornig – Columbia University Hornig used one mouse strain with genetic Hg sensitivity and autoimmunity and two strains without them, then replicated the immunization schedule using thimerosal-containing vaccines. Sensitive mice showed significant delay in weight gain. Sensitive mice showed significant delay in weight gain. Sensitive mice had enlarged brains, noted in autistic children. Sensitive mice had enlarged brains, noted in autistic children. Behavioral impoverishment was highly significant the sensitive strain. Behavioral impoverishment was highly significant the sensitive strain. 40 percent of sensitive mice were self-mutilatory at six months, ie, frantically grooming or biting tails. 40 percent of sensitive mice were self-mutilatory at six months, ie, frantically grooming or biting tails. One mouse groomed through partners skull. One mouse groomed through partners skull.

19 Evidence of Harm 19 KNOW YOUR THIOLS Thiol – A class of SULFUR-BASED proteins that bind with heavy metals and eliminate them from the system. Thiol – A class of SULFUR-BASED proteins that bind with heavy metals and eliminate them from the system. Thiols include – Glutathione, cysteine and metallothioneine. Thiols include – Glutathione, cysteine and metallothioneine. Synonym for thiol = mercaptan from the Latin mercurium captans: literally mercury capturer. Synonym for thiol = mercaptan from the Latin mercurium captans: literally mercury capturer.

20 Evidence of Harm 20 Jill James – Glutathione Depletion in Autistic Children Discovered that ASD kids have low or depleted levels of thiols, including glutathione – a powerful antioxidant. Discovered that ASD kids have low or depleted levels of thiols, including glutathione – a powerful antioxidant. Thiols, are the bodys natural defenses again heavy metals. Thiols, are the bodys natural defenses again heavy metals. Low thiols levels are thought to be based on genes - and possible mercury exposure (See: R. Deth). Low thiols levels are thought to be based on genes - and possible mercury exposure (See: R. Deth).

21 Evidence of Harm 21 BURBACHER STUDY Univ. of Washington Primate Ctr. Compared ethylmercury from thimerosal and methylmercury from fish. Compared ethylmercury from thimerosal and methylmercury from fish. Methylmercury remained in blood longer and crossed blood-brain barrier more. Methylmercury remained in blood longer and crossed blood-brain barrier more. Govt press release and media reported the message: Ethylmercury is less hazardous. Govt press release and media reported the message: Ethylmercury is less hazardous. BUT - Ethyl degrades into inorganic mercury much faster than methyl. Twice as much inorganic Hg deposited in brains of the ethyl over methyl group. Twice as much inorganic Hg deposited in brains of the ethyl over methyl group. Half the methyl-exposed brains had no detectable inorganic Hg Half the methyl-exposed brains had no detectable inorganic Hg Inorganic Hg trapped in brain can spark immune response, activation of glial cells, inflammation – average delay of symptoms was 6 months! Inorganic Hg trapped in brain can spark immune response, activation of glial cells, inflammation – average delay of symptoms was 6 months!

22 Evidence of Harm 22 HARVARD & JOHNS HOPKINS STUDIES ON AUTISTIC BRAINS HARVARD: Neuro-inflammation found in autistic brain tissue from childhood through adulthood. Study suggests that chronic disease or an external environmental source (ie, heavy metals) may be cause. Neuro-inflammation found in autistic brain tissue from childhood through adulthood. Study suggests that chronic disease or an external environmental source (ie, heavy metals) may be cause. JOHNS HOPKINS: Inflammation found in autistic brains - apparently associated with activation of brains immune system. Inflammation found in autistic brains - apparently associated with activation of brains immune system. Compared with controls, autistic tissue showed ongoing inflammation in various sections of brain. Compared with controls, autistic tissue showed ongoing inflammation in various sections of brain. Inflammation was produced by activation of brain cells known as microglia and astroglia.

23 Evidence of Harm 23 Coal Emissions a Risk Factor? University of Texas – Published in Health and Place – Hg from coal-fired power plants may increase ASD risk. University of Texas – Published in Health and Place – Hg from coal-fired power plants may increase ASD risk. Study looked at Texas county levels of emissions, compared to ASD rates and special ed in 1,200 school districts. Autism increased as mercury emissions rose. For every thousand pounds of Hg, there was a 61 percent increase in autism rates. Study looked at Texas county levels of emissions, compared to ASD rates and special ed in 1,200 school districts. Autism increased as mercury emissions rose. For every thousand pounds of Hg, there was a 61 percent increase in autism rates. One county with low mercury emissions but significant autism rates was found to harbor one of the nations largest mercury mines. One county with low mercury emissions but significant autism rates was found to harbor one of the nations largest mercury mines. Author: A potentially important connection between environmental exposure to mercury and the development of autism. Author: A potentially important connection between environmental exposure to mercury and the development of autism.

24 Evidence of Harm 24 California Kaiser Study – Funded By CDC 284 ASD children 657 controls, born in 1994 in the SF Bay Area. 284 ASD children 657 controls, born in 1994 in the SF Bay Area. Assigned exposure level by census tract of birth for 19 chemicals. Assigned exposure level by census tract of birth for 19 chemicals. Risks for ASD were elevated by 50% in the tracts with the highest chlorinated solvents and heavy metals. Risks for ASD were elevated by 50% in the tracts with the highest chlorinated solvents and heavy metals. Risk from heavy metals was almost twice as high as solvents. Risk from heavy metals was almost twice as high as solvents. Highest risk compounds were mercury, cadmium, nickel, trichloroethylene, and vinyl chloride. Highest risk compounds were mercury, cadmium, nickel, trichloroethylene, and vinyl chloride. Our results suggest a potential association between autism and estimated metal concentrations, and possibly solvents, in ambient air around the birth residence. Our results suggest a potential association between autism and estimated metal concentrations, and possibly solvents, in ambient air around the birth residence.

25 25 AGAINST THE THIMEROSAL THEORY: MAJOR PLAYERS ELI LILLY & CO – Invented product, has license agreements until 2010; defendant in lawsuits. ELI LILLY & CO – Invented product, has license agreements until 2010; defendant in lawsuits. MERCK, GLAXO, ETC – Vaccine makers, lawsuit defendants. MERCK, GLAXO, ETC – Vaccine makers, lawsuit defendants. FDA – Asleep at the switch - Failed to add Hg totals; no safety studies; poor lit review (missed articles in own library); refusal to recall. FDA – Asleep at the switch - Failed to add Hg totals; no safety studies; poor lit review (missed articles in own library); refusal to recall. CDC – Conflict in promoting and monitoring vaccines; aggressive use of immunization schedule; secret analyses of embargoed government data; funding of questionable studies; refusal to recommend Hg-free vaccines. CDC – Conflict in promoting and monitoring vaccines; aggressive use of immunization schedule; secret analyses of embargoed government data; funding of questionable studies; refusal to recommend Hg-free vaccines.

26 26 AGAINST THE THIMEROSAL THEORY: MAJOR POINTS No epidemic of autism (the Hidden Horde?). No epidemic of autism (the Hidden Horde?). Hg levels in vaccines very low. Hg levels in vaccines very low. Ethyl Hg less toxic than Methyl Hg (Pichichero, NIAID, Offit). Ethyl Hg less toxic than Methyl Hg (Pichichero, NIAID, Offit). Autism not same as Hg poisoning (Nelson & Bauman). Autism not same as Hg poisoning (Nelson & Bauman). Theory is motivated by greed, emotion, & revenge. Theory is motivated by greed, emotion, & revenge. 4-year CDC study of federal database shows little to no neurological damage from Hg in childhood vaccines. 4-year CDC study of federal database shows little to no neurological damage from Hg in childhood vaccines. No consistent evidence of harm found in five major epidemiological studies: IOM. No consistent evidence of harm found in five major epidemiological studies: IOM.

27 Evidence of Harm 27 THIMEROSAL EXPOSURE & AUTISM RATES IN DENMARK 1981-2000

28 Evidence of Harm 28 VSD 5 GENERATIONS

29 29 Generation Zero Nov-Dec 1999 Recently rediscovered. First run of the numbers. Very high relative risks for outcomes. Autism RR = 7.6 UNPUBLISHED STUDY OBTAINED THROUGH FOIA UNPUBLISHED STUDY OBTAINED THROUGH FOIA

30 Evidence of Harm 30 VSD: Generation Zero

31 Evidence of Harm 31 Generation 1 Verstraeten 2/2000 Verstraeten reruns numbers, risks are lower. Still, significant outcomes just wont go away. Autism RR = 2.48 UNPUBLISHED STUDY OBTAINED THROUGH FOIA

32 Evidence of Harm 32 IT JUST WONT GO AWAY

33 Evidence of Harm 33 VSD Generation 1: Autism (Verstraeten – 2/2000)

34 Evidence of Harm 34 VSD Generation 2: Autism (Simpsonwood & ACIP 6/2000)

35 Evidence of Harm 35 Generation 2: NDDs (Simpsonwood & ACIP 6/2000)

36 Evidence of Harm 36 Generation 2: Language Disorder (Simpsonwood & ACIP 6/2000)

37 Evidence of Harm 37 VSD Generation 3: Autism (IOM Presentation 7/2001)

38 Evidence of Harm 38 Generation 4: Autism (Pediatrics Article, 11/2003) Vol. 112 No. 5 November 2003, pp. 1039-1048 In no analyses were significant increased risks found for autism or attention-deficit disorder.

39 Evidence of Harm Autism Risks Across 5 Generations GEN 0GEN 1GEN 2GEN 3 GEN 4 7.62 2.48 1.69 1.52 0.00

40 Evidence of Harm 40

41 Evidence of Harm 41 AVENUES OF INVESTIGATION?

42 Evidence of Harm 42 US SENATE ACTION Mike Enzi (R-WY) and H.E.L.P Committee investigators Mike Enzi (R-WY) and H.E.L.P Committee investigators Joe Lieberman (D-CT) – Bill to open up access to VSD – RECENT LETTER TO NIEHS Joe Lieberman (D-CT) – Bill to open up access to VSD – RECENT LETTER TO NIEHS Dodd (D-CT) and Santorum (R-PA) on record (Imus) in favor of inquest Dodd (D-CT) and Santorum (R-PA) on record (Imus) in favor of inquest Chuck Hagel (R-NE) Bill to ban mercury in Vaccines Chuck Hagel (R-NE) Bill to ban mercury in Vaccines Combating Autism Act – Wait for 2007? Combating Autism Act – Wait for 2007?

43 Evidence of Harm 43 Letter from Sen. Lieberman et al to the NIEHS, RE: VSD Access

44 Evidence of Harm 44 DATA SETS GO MISSING Federal law requires all publicly funded data and datasets be properly maintained. A felony to deliberately lose or destroy records. CDC official testified that some datasets hadnt been archived in a standard manner, and, may not allow all the re-analyses that one might want to do, or in fact may not be available at all. IOM committee, citing federal Information Quality Act, recommended that vaccine officials seek legal advice.

45 Evidence of Harm 45 WHY DID IOM BASE ITS DECISION ON EPI STUDIES? Epidemiology not acceptable to disprove causation: Federal Court System. Epidemiology not acceptable to disprove causation: Federal Court System. Epidemiological studies were questioned by lead investigators themselves, ie-- Epidemiological studies were questioned by lead investigators themselves, ie-- Danish authors: exponential expansion of patients (inpatient-outpatient) may have spuriously increased the apparent number of autism cases. Danish authors: exponential expansion of patients (inpatient-outpatient) may have spuriously increased the apparent number of autism cases. Verstraeten: We found no evidence against an association, as a negative study would. On the contrary, additional study is recommended, which is the conclusion to which a neutral study must come. Verstraeten: We found no evidence against an association, as a negative study would. On the contrary, additional study is recommended, which is the conclusion to which a neutral study must come. IOM final report: Cannot rule out, based on the epidemiology, possibility that vaccines contribute to autism in some small subset. IOM final report: Cannot rule out, based on the epidemiology, possibility that vaccines contribute to autism in some small subset.

46 Evidence of Harm 46 DID CDC EXERT UNDUE PRESSURE ON IOM? Kathleen Stratton: The line we will not cross in public policy is to pull the vaccine, change the schedule. Kathleen Stratton: The line we will not cross in public policy is to pull the vaccine, change the schedule. Gerald Medoff: You just want us to say the evidence favors rejection of the hypothesis? Gerald Medoff: You just want us to say the evidence favors rejection of the hypothesis? McCormick: Yes, thats what they want to say. McCormick: Yes, thats what they want to say.

47 Evidence of Harm 47 STILL MORE IOM QUOTES Stratton: There are pros and cons of letting them determine the topic– to be expedient, it is better that they determine it. Stratton: There are pros and cons of letting them determine the topic– to be expedient, it is better that they determine it. Alfred Berg: They are paying for it. Alfred Berg: They are paying for it. Stratton: We can shape it a little. We have-- you know, what are the boundaries. Does that make you feel any better? Stratton: We can shape it a little. We have-- you know, what are the boundaries. Does that make you feel any better? Berg: Now I am curious what other parts of the methods CDC has figured out for us. Berg: Now I am curious what other parts of the methods CDC has figured out for us. Berg: CDC is one of the malefactors on this issue, because they are always pushing to go beyond the data and say yes, vaccines are safe. Berg: CDC is one of the malefactors on this issue, because they are always pushing to go beyond the data and say yes, vaccines are safe.

48 Evidence of Harm 48 IOM CHANGES RULES OF ENGAGEMENT HALFWAY THROUGH Went from looking at biological plausibility to biological mechanisms Went from looking at biological plausibility to biological mechanisms IOM said plausibility was confusing IOM said plausibility was confusing But biological mechanisms of autism are unknown But biological mechanisms of autism are unknown

49 Evidence of Harm 49

50 50 3-5 year olds - quarterly numbers are mixed QUARTERTotal # children Net gain Change 3-5 years old (Avg. 143)net gain 1Q 2003 4228 189 +81 1Q 2003 4228 189 +81 2Q 2003 4466238 +49 2Q 2003 4466238 +49 3Q 2003 455892-146 3Q 2003 455892-146 4Q 2003 461153 -39 4Q 2003 461153 -39 1Q 2004 4793182+129 1Q 2004 4793182+129 2Q 2004 4894101 -81 2Q 2004 4894101 -81 3Q 2004 4997103 +2 3Q 2004 4997103 +2 4Q 2004 5156159 +56 4Q 2004 5156159 +56 1Q 2005 5307151 -8 1Q 2005 5307151 -8 2Q 2005 5446139 -12 2Q 2005 5446139 -12 3Q 2005 5539 93 -46 3Q 2005 5539 93 -46 4Q 2005 5680141+48 4Q 2005 5680141+48 1Q 2006 5827147 +6 1Q 2006 5827147 +6 2Q 2006 6083256 +109 2Q 2006 6083256 +109 3Q 2006 6188105 -151 3Q 2006 6188105 -151

51 Evidence of Harm 51 NET GAINS BY 3D QUARTER 2003519 2003519 2004386 2004386 2005383 2005383 2006508 2006508

52 Evidence of Harm 52 Yearly trends for 3-5 year olds YearNet Gain % Change ages 3-5 2003572n/a 2004545-4.72% 2005524-3.85% 2006 (3Q)508+???

53 Evidence of Harm 53 But the 2 nd Quarter 2006 is an Alarming Spike Highest gains ever posted Highest gains ever posted Immigration spike? Immigration spike? Baby boomlet? Baby boomlet? Early intervention? Early intervention? Wildfires/pollution? Wildfires/pollution? Flu shot? Flu shot?

54 Evidence of Harm 54 Why the flu shot may matter If a pregnant woman receives 25mcg, much of that will end up in fetus. If a pregnant woman receives 25mcg, much of that will end up in fetus. A 1lb fetus (0.5kg) receiving 10mcg is 200 times over EPA limit. A 1lb fetus (0.5kg) receiving 10mcg is 200 times over EPA limit. 0.25kg fetus receiving 20mcg is 800 times over EPA. 0.25kg fetus receiving 20mcg is 800 times over EPA. At 6 months, a 16lb baby receives 12.5mcg – 17 times over limit. At 6 months, a 16lb baby receives 12.5mcg – 17 times over limit. At 7 months, same baby receives 12.5 mcg. At 7 months, same baby receives 12.5 mcg. Other shots contain 5-10mcg in residual Hg. Other shots contain 5-10mcg in residual Hg. Total possible exposure by 7 mos: 55mcg. Total possible exposure by 7 mos: 55mcg.

55 Evidence of Harm 55 TRENDS IN WEIGHT ADJUSTED THIMEROSAL EXPOSURES FROM CHILDHOOD VACCINES AND INFLUENZA VACCINES DURING PREGNANCY AND EARLY INFANCY Cumulative bolus mercury dose from vaccines through 24 months (mcg/kg) Year of birth From the childhood immunization schedule From the influenza vaccine in utero/infancy Exposure from continued TCV production and related inventory

56 Evidence of Harm 56 THE SCIENCE: SEARCH FOR A CURE

57 Evidence of Harm 57 MERCAPTANS AT WORK MERCAPTANS AT WORK Two main chelating agents: DMSA: Di-Mercapto-Succinic Acid IV, or more typically in children, orally. Most commonly used. Safest? DMPS: Di-Mercapto-Propane-Sulfonate Transdermal patch. Controversial and untested. Anecdotal evidence shows great potency. Miraculous recoveries reported by parents and doctors.

58 Evidence of Harm 58 Porphyrins and Hg Burden Urine samples from 100s of French yielded evidence for a link between autism and heavy metals. Urine samples from 100s of French yielded evidence for a link between autism and heavy metals. Samples from ASD children had high levels of proteins called porphyrins – used to produce of haem, the oxygen- carrying component in haemoglobin. Heavy metals block haem, causing porphyrins to accumulate in urine. Coproporphyrin was 2.6 times higher in ASD children than controls. Samples from ASD children had high levels of proteins called porphyrins – used to produce of haem, the oxygen- carrying component in haemoglobin. Heavy metals block haem, causing porphyrins to accumulate in urine. Coproporphyrin was 2.6 times higher in ASD children than controls. Richard Lathe of Pieta Research in Edinburgh: Highly likely heavy metals are responsible for childhood ASD in a majority of cases -- Toxicology and Applied Pharmacology. Richard Lathe of Pieta Research in Edinburgh: Highly likely heavy metals are responsible for childhood ASD in a majority of cases -- Toxicology and Applied Pharmacology. Lathe says porphyrin metabolites bind to receptors in the brain and have been linked with epilepsy and autism. Lathe says porphyrin metabolites bind to receptors in the brain and have been linked with epilepsy and autism. Researchers restored porphyrin concentrations to normal in 12 children through chelation. Waiting for clinical results, but Lathe cites anecdotal reports suggesting the drugs might be helping. Researchers restored porphyrin concentrations to normal in 12 children through chelation. Waiting for clinical results, but Lathe cites anecdotal reports suggesting the drugs might be helping.

59 59 JAMES: Rebuild Metabolic Profile? Methionine metabolites (methionine, cysteine, glutathione) in 20 children with autism compared vs. controls revealed severely abnormal profiles. Methionine metabolites (methionine, cysteine, glutathione) in 20 children with autism compared vs. controls revealed severely abnormal profiles. Targeted nutritional intervention for three weeks with Folinic acid, and Betaine (1000 mg. BID) resulted in significant improvement in methylation capacity in children with autism. Targeted nutritional intervention for three weeks with Folinic acid, and Betaine (1000 mg. BID) resulted in significant improvement in methylation capacity in children with autism. Addition of methyl B-12 to cocktail brought all autistic children within normal levels of methionine, cysteine and glutathione Addition of methyl B-12 to cocktail brought all autistic children within normal levels of methionine, cysteine and glutathione

60 Evidence of Harm 60 METHYLATION Occurs billions of times a day within cells Occurs billions of times a day within cells Transfer of a methyl group (1 carbon & 3 hydrogen atoms) from one molecule to another. Transfer of a methyl group (1 carbon & 3 hydrogen atoms) from one molecule to another. Why important? Every cell contains the same DNA and can do same things. Why important? Every cell contains the same DNA and can do same things. Methyl groups shut down genes that arent supposed to be active. Methyl groups shut down genes that arent supposed to be active. Methylation critical to normal DNA function and gene expression. Methylation critical to normal DNA function and gene expression. Also needed for fatty acids for nerve development & myelin sheath. Also needed for fatty acids for nerve development & myelin sheath. Essential for glutathione and thiol production Essential for glutathione and thiol production Greatly impaired by thimerosal in test tube through inhibition of methionine synthase Greatly impaired by thimerosal in test tube through inhibition of methionine synthase

61 Evidence of Harm 61 METHYLATION: NEEDED FOR METHIONINE CYCLE AND TRANSULFURATION PATHWAY

62 Evidence of Harm 62 Thimerosals Legacy? Autism rarely reported outside industrialized countries until recently. Autism rarely reported outside industrialized countries until recently. China: Merck and Glaxo-SmithKline have aggressive pediatric marketing campaigns. China: Merck and Glaxo-SmithKline have aggressive pediatric marketing campaigns. Xinhua: Autism suddenly skyrocketed from nearly nothing to 1.8 million in 2004. BETTER DIAGNOSIS? Xinhua: Autism suddenly skyrocketed from nearly nothing to 1.8 million in 2004. BETTER DIAGNOSIS? 20% growth rate, higher than world average of 14%. 20% growth rate, higher than world average of 14%. Other increases in Indonesia, Argentina, India and Nigeria. Other increases in Indonesia, Argentina, India and Nigeria. What if the profitable export of our much vaunted medical technology has led to the poisoning of tens of thousands of children? What if the profitable export of our much vaunted medical technology has led to the poisoning of tens of thousands of children?


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