5But…What did DNAlook like, and how did it replicate itself?
6Discovering the structure of DNA Rosalind Franklin ( )King’s College, LondonMade significant advances inx- ray diffraction techniqueswith DNAHer images suggested thatDNA had a spiral shapeOne of her DNA images
7Discovering the structure of DNA Maurice Wilkins – ( )King’s College, LondonAlso did X-ray diffraction studiesof DNAWorked with Rosalind FranklinShared information with Watson and Crick
8Discovering the structure of DNA Erwin Chargaff – ( )Columbia University, NYInvestigated the composition of DNAHis findings by 1950 stronglysuggested the base-pairingsof A-T & G-CMet with Watson and Crick in1952 and shared his findings“Chargaff’s rule” A = T & C = G
9Discovering the structure of DNA James Watson (1928) and Francis Crick ( )Worked together at Cavendish Laboratory in Cambridgeto determine the structure of DNAUsed work from Franklin, Wilkins, and Chargaff todetermine the double helix shapeWatson, Crick, and Wilkinswere awarded the Nobel PrizeRosalind Franklin passed away(1958) before the Nobel Prizewas awarded in 1962
10Discovering the structure of DNA DNA = Deoxyribose nucleic acidPresent in all living cellsContains all the informationNucleotides:a subunit that consists of:a sugar (deoxyribose)a phosphateand one nitrogen base – 4 different basesAdenine (A) and Thymine (T)Guanine (G) and Cytosine (C)
11DNA – What does my code look like? Computer Code:DNA Code:ATTCGGGGCCTTAAGACATTAATTTCCCAAGAAGAGATAAACTAGAGAGACCCTTTAAAACACACAGAGATAGACAGAAAAACAATAGACAGATACAGATAGACATAAAAAATTTTTTGGGAAA…millions and millions of bases…“Gattaca” is a science fiction movie starring Uma Thurman, Ethan Hawke, and Jude Law
12G A T T A C A C T A A T G T Practice DNA Base Pairs “Gattaca” is a science fiction movie starring Uma Thurman, Ethan Hawke, and Jude Law